Tert-butyl 2-(aminomethyl)morpholine-4-carboxylate

Base Information

• Chemical Name: Tert-butyl 2-(aminomethyl)morpholine-4-carboxylate
• CAS No.: 140645-53-0
• Molecular Formula: C10H20N2O3
• Molecular Weight: 216.28
• Hs Code.: 2934999090
• European Community (EC) Number: 818-653-2
• ChEMBL ID: CHEMBL4590147
• DSSTox Substance ID: DTXSID60597885
• Mol file: 140645-53-0.mol

Synonyms:140645-53-0;2-Aminomethyl-4-Boc-morpholine;tert-butyl 2-(aminomethyl)morpholine-4-carboxylate;4-Boc-2-Aminomethylmorpholine;4-BOC-2-(AMINOMETHYL)MORPHOLINE;4-MORPHOLINECARBOXYLIC ACID, 2-(AMINOMETHYL)-, 1,1-DIMETHYLETHYL ESTER;2-Aminomethyl-morpholine-4-carboxylic acid tert-butyl ester;2-(Aminomethyl)morpholine, 4-BOC protected;(S)-N-Boc-2-aminomethylmorpholine;MFCD06410633;N-Boc-2-aminomethylmorpholine;MFCD11707017;MFCD13189480;(R)-4-Boc-2-(aminomethyl)morpholine;(S)-4-BOC-2-(AMINOMETHYL)MORPHOLINE;SCHEMBL60605;CHEMBL4590147;DTXSID60597885;MTMBHUYOIZWQAJ-UHFFFAOYSA-N;(R)-4-Boc-2-aminomethylmorpholine;BCP28782;AKOS010592783;CS-W003285;PB10935;PB13585;PB34122;AS-37006;SY007381;SY008101;SY008123;(R)-N-BOC-2-AMINOMETHYLMORPHOLINE;2-aminomethyl-4-Boc-morpholine, AldrichCPR;DB-020530;AM20080305;EN300-99308;tert-butyl2-(aminomethyl)morpholine-4-carboxylate;W-205543;Z803081050

Chemical Property of Tert-butyl 2-(aminomethyl)morpholine-4-carboxylate

Chemical Property:

• Vapor Pressure: 0.000589mmHg at 25°C
• Refractive Index: 1.477
• Boiling Point: 310.723 °C at 760 mmHg
• PKA: 9.37±0.29(Predicted)
• Flash Point: 141.72 °C
• PSA: 64.79000
• Density: 1.079 g/cm³
• LogP: 1.21920
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• XLogP3: -0.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 216.14739250
• Heavy Atom Count: 15
• Complexity: 225

Purity/Quality:

98% or more ^*data from raw suppliers

4-Boc-(2-aminomethyl)morpholine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,T
• Statements: 25
• Safety Statements: 45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)OC(=O)N1CCOC(C1)CN
• Uses: 4-Boc-(2-aminomethyl)morpholine is used as a reagent in the discovery of novel small molcules that activate satellite cell proliferation and enhance repair of damaged muscle.

Technology Process of Tert-butyl 2-(aminomethyl)morpholine-4-carboxylate

There total 1 articles about Tert-butyl 2-(aminomethyl)morpholine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

N-[[4-(tert-butoxycarbonyl)morpholin-2-yl]methyl]phthalimide (876147-52-3) → 2-(aminomethyl)morpholine-4-carboxylic acid tert-butyl ester (140645-53-0)

Guidance literature:

N-[[4-(tert-butoxycarbonyl)morpholin-2-yl]methyl]phthalimide; With hydrazine; In methanol; for 4h; Heating / reflux;

With potassium hydroxide; In water;

Reference yield: 97.0%

2-(aminomethyl)morpholine-4-carboxylic acid tert-butyl ester (140645-53-0) + 4-(5-chlorofuran-2-yl)-1,3-bis(2,4-difluorophenyl)-5-methyl-4,5-dihydro-1H-pyrazole-5-carboxylic acid → tert-butyl 2-((4-(5-chlorofuran-2-yl)-1,3-bis(2,4-difluorophenyl)-5-methyl-4,5-dihydro-1H-pyrazole-5-carboxamido)methyl)morpholine-4-carboxylate

Guidance literature:

4-(5-chlorofuran-2-yl)-1,3-bis(2,4-difluorophenyl)-5-methyl-4,5-dihydro-1H-pyrazole-5-carboxylic acid; With 4-methyl-morpholine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h;

2-(aminomethyl)morpholine-4-carboxylic acid tert-butyl ester; In N,N-dimethyl-formamide; for 18h;

Reference yield: 89.33%

4-fluoro-3-nitrobenzenesulfonamide (406233-31-6) + 2-(aminomethyl)morpholine-4-carboxylic acid tert-butyl ester (140645-53-0) → 2-(((2-nitro-4-sulfamoylphenyl)amino)methyl)morpholine-4-carboxylic acid tert-butyl ester

Guidance literature:

With sodium carbonate; In isopropyl alcohol; at 55 - 65 ℃; for 4h;

upstream raw materials:

N-[[4-(tert-butoxycarbonyl)morpholin-2-yl]methyl]phthalimide

Downstream raw materials:

4-amino-N-[{4-(tert-butoxycarbonyl)-2-morpholinyl}methyl]-5-chloro-2-methoxybenzamide

(morpholin-2-yl-methyl)-[7-(4-morpholin-4-yl-phenyl)-[1,6]naphthyridin-5-yl]-amine

N-(morpholin-2-ylmethyl)-2-(4-chlorophenyl)-4-methylthiazole-5-carboxamide

N-[[4-(tert-butoxycarbonyl)morpholin-2-yl]methyl]-2-(4-chlorophenyl)-4-methylthiazole-5-carboxamide

Refernces

• 1、 -. "NOVEL CYCLIC AMINOBENZOIC ACID DERIVATIVE". Page/Page column 57. . Retrieved 2010/11/27.