Technology Process of tert-butyl 4-{[({3-[(benzylsulfonyl)amino]-2,6-difluorophenyl}acetyl)amino]methyl}piperidine-1-carboxylate
There total 7 articles about tert-butyl 4-{[({3-[(benzylsulfonyl)amino]-2,6-difluorophenyl}acetyl)amino]methyl}piperidine-1-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
{3-[(benzylsulfonyl)amino]-2,6-difluorophenyl}acetic acid;
With
PS-carbodiimide; benzotriazol-1-ol;
In
dichloromethane; N,N-dimethyl-formamide;
for 0.25h;
tert-butyl 4-(aminomethyl)piperidine-1-carboxylate;
In
dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm030233b
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 61 percent / iPr2NEt / CH2Cl2 / 20 h / 20 °C
2.1: 95 percent / aq. NaOH / methanol / 65 °C
3.1: 1-hydroxybenzotriazole; PS-carbodiimide / CH2Cl2; dimethylformamide / 0.25 h
3.2: 100 percent / CH2Cl2; dimethylformamide
With
sodium hydroxide; PS-carbodiimide; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine;
In
methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm030233b
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: 91 percent / HNO3 / methanol / 0.25 h / -10 °C
2.1: oxalyl chloride; DMF / CH2Cl2 / 20 °C
3.1: 5.47 g / pyridine / CH2Cl2 / 20 °C
4.1: 68 percent / Fe; glacial acetic acid / 80 °C
5.1: 61 percent / iPr2NEt / CH2Cl2 / 20 h / 20 °C
6.1: 95 percent / aq. NaOH / methanol / 65 °C
7.1: 1-hydroxybenzotriazole; PS-carbodiimide / CH2Cl2; dimethylformamide / 0.25 h
7.2: 100 percent / CH2Cl2; dimethylformamide
With
pyridine; sodium hydroxide; PS-carbodiimide; oxalyl dichloride; nitric acid; iron; benzotriazol-1-ol; acetic acid; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide;
In
methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm030233b