2,2-dichloro-2-phenylacetyl chloride

Base Information

• Chemical Name: 2,2-dichloro-2-phenylacetyl chloride
• CAS No.: 4773-36-8
• Molecular Formula: C₈H₅Cl₃O
• Molecular Weight: 223.486
• Mol file: 4773-36-8.mol

Synonyms:2,2-dichloro-2-phenylacetyl chloride

Chemical Property of 2,2-dichloro-2-phenylacetyl chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,2-dichloro-2-phenylacetyl chloride

There total 5 articles about 2,2-dichloro-2-phenylacetyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

phenylacetyl chloride (103-80-0) → 2,2-dichloro-2-phenylacetyl chloride (4773-36-8)

Guidance literature:

With tetrabutyl-ammonium chloride; oxygen; chlorine; at 120 - 125 ℃; for 10h; Darkness; Neat (no solvent);

DOI:10.1055/s-0031-1289678

Reference yield:

dichlorophenyl-acetic acid (61031-72-9) → 2,2-dichloro-2-phenylacetyl chloride (4773-36-8)

Guidance literature:

With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 - 40 ℃;

DOI:10.1016/S0040-4020(97)00908-3

Reference yield:

methyl 2,2-dichloro-2-phenylacetate (81265-15-8) → 2,2-dichloro-2-phenylacetyl chloride (4773-36-8)

Guidance literature:

Multi-step reaction with 2 steps

1: LiOH / propan-2-ol; H₂O / 0.25 h / -7 °C

2: oxalyl chloride, DMF / CH₂Cl₂ / 20 - 40 °C

With lithium hydroxide; oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; water; isopropyl alcohol;

DOI:10.1016/S0040-4020(97)00908-3

upstream raw materials:

phenylacetyl chloride

Benzoylformic acid

dichlorophenyl-acetic acid

methyl 2,2-dichloro-2-phenylacetate

Downstream raw materials:

2,2-Dichloro-N-(octahydro-naphthalen-4a-yl)-2-phenyl-acetamide

N,N-Diethyl-2,2-dichloro-phenyl-acetamid

2,2-Dichlor-phenylessigsaeure-

2,2-Dichlor-2-phenylacetomorpholid

Refernces

• 1、 Benedetti, Miriam,Forti, Luca,Ghelfi, Franco,Pagnoni, Ugo Maria,Ronzoni, Roberto. "Halogen atom transfer radical cyclization of N-allyl-N-benzyl-2,2-dihaloamides to 2-pyrrolidinones, promoted by Fe0-FeCl3 or CuCl-TMEDA". . p. 14031 - 14042. Retrieved 2007/10/03.