4-(4-Iodophenyl)morpholine

Base Information

• Chemical Name: 4-(4-Iodophenyl)morpholine
• CAS No.: 87350-77-4
• Molecular Formula: C10H12INO
• Molecular Weight: 289.116
• Hs Code.: 2934999090
• European Community (EC) Number: 686-008-0
• DSSTox Substance ID: DTXSID90383632
• Nikkaji Number: J1.603.173I
• Wikidata: Q82175418
• Mol file: 87350-77-4.mol

Synonyms:4-(4-Iodophenyl)morpholine;87350-77-4;Morpholine,4-(4-iodophenyl)-;MFCD04974040;4-iodophenylmorpholine;Morpholine, 4-(4-iodophenyl)-;4-(4-Iodophenyl)-morpholine;SCHEMBL1432961;DTXSID90383632;YUEREUIIUISPFV-UHFFFAOYSA-N;4-(4-Iodophenyl)morpholine, 97%;AMY32829;AKOS022177960;AS-47002;SY225816;CS-0045071;F11188;A916056;J-513527

Chemical Property of 4-(4-Iodophenyl)morpholine

Chemical Property:

• Vapor Pressure: 2.53E-05mmHg at 25°C
• Melting Point: 146℃
• Refractive Index: 1.614
• Boiling Point: 358.6 °C at 760 mmHg
• PKA: 4.22±0.40(Predicted)
• Flash Point: 170.7 °C
• PSA: 12.47000
• Density: 1.653 g/cm³
• LogP: 2.19280
• Sensitive.: Air Sensitive
• XLogP3: 2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 288.99636
• Heavy Atom Count: 13
• Complexity: 151

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-(4-Iodophenyl)morpholine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 22-52/53
• Safety Statements: 61

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COCCN1C2=CC=C(C=C2)I

Technology Process of 4-(4-Iodophenyl)morpholine

There total 9 articles about 4-(4-Iodophenyl)morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-Phenylmorpholine (92-53-5) → N-(4-iodophenyl)morpholine (87350-77-4)

Guidance literature:

With periodic acid; potassium iodide; In dichloromethane; water; at 20 ℃; for 0.25h;

DOI:10.1002/hlca.200900259

Reference yield: 95.0%

morpholine (110-91-8,99108-56-2) + 4-iodophenyl trifluoromethanesulfonate (109586-39-2) → N-(4-iodophenyl)morpholine (87350-77-4)

Guidance literature:

In 1-methyl-pyrrolidin-2-one; at 200 - 204 ℃; for 0.75h; microwave irradiation;

DOI:10.1021/ol049963j

Reference yield: 80.0%

4-morpholino-4-yl-phenylamine (2524-67-6,86759-37-7) → N-(4-iodophenyl)morpholine (87350-77-4)

Guidance literature:

4-morpholino-4-yl-phenylamine; With water; sodium nitrite; In neat (no solvent); at 20 ℃;

With potassium iodide; In neat (no solvent); at 20 ℃;

DOI:10.1016/j.tetlet.2014.02.073

upstream raw materials:

4-Phenylmorpholine

morpholine

para-diiodobenzene

4-iodophenyl trifluoromethanesulfonate

Downstream raw materials:

4-(4-trifluoromethylphenyl)morpholine

4-[4-(phenylethynyl)phenyl]morpholine

3-(4-morpholin-4-yl-phenyl)-prop-2-yn-1-ol

Refernces

• 1、 Bovonsombat, Pakorn,Lorpaiboon, Wanutcha,Laoboonchai, Sarocha,Sriprachaya-anunt, Prima,Yimkosol, Warangkana,Siriphatcharachaikul, Natthapatch,Siricharoensang, Pornpawit,Kangwannarakul, Terawee,Maeda, Jin,Losuwanakul, Satreerat,Mahesh Abhyankar, Maitraye. "A novel DMSO-assisted regioselective iodination of aniline analogues". . . Retrieved 2020/10/05.
• 2、 -. "PHARMACEUTICALLY EFFECTIVE COMPOUNDS INHIBITING SELECTIVELY THE MYOSIN 2 ISOFORMS". Page/Page column 38-39. . Retrieved 2019/11/12.