2-BROMO-5-IODOPYRAZINE

Base Information

• Chemical Name: 2-BROMO-5-IODOPYRAZINE
• CAS No.: 622392-04-5
• Molecular Formula: C4H2BrIN2
• Molecular Weight: 284.882
• Hs Code.: 2933990090
• Mol file: 622392-04-5.mol

Synonyms:2-Bromo-5-iodopyrazine;5-Bromo-2-iodopyrazine;

Chemical Property of 2-BROMO-5-IODOPYRAZINE

Chemical Property:

• Vapor Pressure: 0.009mmHg at 25°C
• Melting Point: 95-97 °C
• Refractive Index: 1.678
• Boiling Point: 273.708 °C at 760 mmHg
• PKA: -4.29±0.10(Predicted)
• Flash Point: 119.335 °C
• PSA: 25.78000
• Density: 2.496 g/cm³
• LogP: 1.84370
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Bromo-5-iodopyrazine 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-BROMO-5-IODOPYRAZINE

There total 1 articles about 2-BROMO-5-IODOPYRAZINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

5-amino-2-bromopyrazine (59489-71-3) → 2-bromo-5-iodo-pyrazine (622392-04-5)

Guidance literature:

With copper(l) iodide; iodine; cesium iodide; isopentyl nitrite; In 1,2-dimethoxyethane; at 60 ℃; for 0.583333h;

Reference yield: 95.0%

(2R)-methylpiperazine (75336-86-6) + 2-bromo-5-iodo-pyrazine (622392-04-5) → 5'-iodo-3-methyl-3,4,5,6-tetrahydro-2H-[1,2']bipyrazinyl (1093063-97-8)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 100 ℃;

Reference yield: 94.0%

2-bromo-5-iodo-pyrazine (622392-04-5) + 3,4,5-tridodecyloxyphenylacetylene (437762-53-3) → 2-bromo-5-(3,4,5-tridodecyloxyphenylethynyl)pyrazine (649774-80-1)

Guidance literature:

With copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride; at 20 ℃; for 2h;

DOI:10.1002/chem.200305073

upstream raw materials:

5-amino-2-bromopyrazine

Downstream raw materials:

2-bromo-5-(3,4,5-tridodecyloxyphenylethynyl)pyrazine

2-(5-bromo-2-pyrazinylethynyl)-5-(3,4,5-tridodecyloxyphenylethynyl)pyrazine

2-iodo-5-methoxy-pyrazine

5'-iodo-3-methyl-3,4,5,6-tetrahydro-2H-[1,2']bipyrazinyl

Refernces

• 1、 Bronner, Catherine,Wenger, Oliver S.. "Long-range proton-coupled electron transfer in phenol-Ru(2,2′- bipyrazine)32+ dyads". . p. 3617 - 3622. Retrieved 2014/02/14.
• 2、 -. "3 -AZABICYCLO [4.1.0] HEPTANES USED AS OREXIN ANTAGONISTS". Page/Page column 61. . Retrieved 2010/11/05.