2-Furyl(2-thienyl)methanone

Base Information

• Chemical Name: 2-Furyl(2-thienyl)methanone
• CAS No.: 20409-51-2
• Molecular Formula: C₉H₆O₂S
• Molecular Weight: 178.211
• DSSTox Substance ID: DTXSID60397185
• Nikkaji Number: J260.207E
• Wikidata: Q82198309
• Mol file: 20409-51-2.mol

Synonyms:2-Furyl(2-thienyl)methanone;furan-2-yl(thiophen-2-yl)methanone;20409-51-2;2-furyl 2-thienyl ketone;2-(thiophene-2-carbonyl)furan;SCHEMBL11124320;DTXSID60397185;furan-2-yl-thiophen-2-ylmethanone;2-[(thiophen-2-yl)carbonyl]furan;MFCD00094043;STK666566;AKOS003655542;BB 0221020;CS-0318325;F2148-0258

Chemical Property of 2-Furyl(2-thienyl)methanone

Chemical Property:

• XLogP3: 2.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 178.00885060
• Heavy Atom Count: 12
• Complexity: 181

Purity/Quality:

99%min ^*data from raw suppliers

Furan-2-yl(thiophen-2-yl)methanone 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=COC(=C1)C(=O)C2=CC=CS2

Technology Process of 2-Furyl(2-thienyl)methanone

There total 15 articles about 2-Furyl(2-thienyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

thiophene (188290-36-0,8014-23-1,25233-34-5) + 2-furancarbonyl chloride (527-69-5) → (furan-2-yl)(thiophen-2-yl)methanone (20409-51-2)

Guidance literature:

With ethylaluminum dichloride; In dichloromethane; at 0 ℃; for 2h; Inert atmosphere;

DOI:10.14233/ajchem.2013.15607

Reference yield: 92.0%

N-(2-furanyl-2-thienylmethylene)aniline (123209-22-3) → (furan-2-yl)(thiophen-2-yl)methanone (20409-51-2)

Guidance literature:

With hydrogenchloride; In methanol;

DOI:10.1021/jo00287a028

Reference yield: 89.0%

2-furancarbonyl chloride (527-69-5) + di-[2]thienyl-mercury (5980-89-2) → (furan-2-yl)(thiophen-2-yl)methanone (20409-51-2) + 2,2'-Bithiophene (492-97-7)

Guidance literature:

With sodium iodide; (4-nitrophenyl)Pd(P(C₆H₅)3)2I; In acetone; at 20 ℃; for 0.166667h; under 0.001 Torr;

DOI:10.1016/0022-328X(89)87037-8

upstream raw materials:

thiophene

2-furancarbonyl chloride

trichloro-(furan-2-carbonyloxy)-silane

furan

Refernces

• 1、 ünver, Halil,Biyikoglu, Mutluhan,Bulut, Adnan. "Non-acidic mediated friedel-craft reaction of thiophene using EtAlCl 2". . p. 8772 - 8774. Retrieved 2013/11/06.
• 2、 Xin, Bingwei,Zhang, Yuhong,Cheng, Kai. "The surfactant-promoted cross-coupling reactions of arylboronic acids with carboxylic anhydrides or acyl chlorides in water". . p. 1970 - 1978. Retrieved 2008/02/12.