4-(4-BUTOXYPHENYL)-4-OXOBUTANOIC ACID

Base Information

• Chemical Name: 4-(4-BUTOXYPHENYL)-4-OXOBUTANOIC ACID
• CAS No.: 63471-88-5
• Molecular Formula: C14H18 O4
• Molecular Weight: 250.295
• Hs Code.: 2918990090
• Mol file: 63471-88-5.mol

Synonyms:Propionicacid, 3-(p-butoxybenzoyl)- (7CI); 3-(4-Butoxybenzoyl)propionic acid;3-(p-Butoxybenzoyl)propionic acid

Chemical Property of 4-(4-BUTOXYPHENYL)-4-OXOBUTANOIC ACID

Chemical Property:

• Vapor Pressure: 1.13E-08mmHg at 25°C
• Melting Point: 112 °C
• Boiling Point: 444.2°C at 760 mmHg
• PKA: 4.59±0.17(Predicted)
• Flash Point: 166.7°C
• PSA: 63.60000
• Density: 1.126g/cm³
• LogP: 2.91300

Purity/Quality:

98%Min ^*data from raw suppliers

4-(4-Butoxypheny)-4-oxobutanoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi:Irritant
• Statements: R36/37/38:Irritating to eyes, respiratory system and skin.
• Safety Statements: S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.; S37/39:Wear suitable g

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-(4-Butoxypheny)-4-oxobutanoic Acid is a useful reagent for the preparation of 3-amino-2-hydroxybutanamide derivatives as β-secretase inhibitors for treatment of Alzheimer''s disease.

Technology Process of 4-(4-BUTOXYPHENYL)-4-OXOBUTANOIC ACID

There total 3 articles about 4-(4-BUTOXYPHENYL)-4-OXOBUTANOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

succinic acid anhydride (108-30-5) + n-butyl phenyl ether (1126-79-0) → 4-(4-butoxy-phenyl)-4-oxo-butyric acid (63471-88-5)

Guidance literature:

With aluminium trichloride; nitrobenzene;

Reference yield:

1-bromo-butane (109-65-9) + 4-(4-hydroxyphenyl)-4-oxobutanoic acid ethyl ester (66123-43-1) → 4-(4-butoxy-phenyl)-4-oxo-butyric acid (63471-88-5)

Guidance literature:

With potassium carbonate; acetone; Erhitzen des Reaktionsprodukts mit wss. Natronlauge;

Reference yield:

→ 4-(4-butoxy-phenyl)-4-oxo-butyric acid (63471-88-5)

Guidance literature:

2,3-Dichlor-4-<4-butoxy-phenyl>-Δ^2,3-crotonlacton (IX), Zinkpulver, A., wss. Essigs., Erh.;

upstream raw materials:

succinic acid anhydride

n-butyl phenyl ether

1-bromo-butane

4-(4-hydroxyphenyl)-4-oxobutanoic acid ethyl ester

Refernces