6-Morpholinonicotinoyl Chloride

Base Information

• Chemical Name: 6-Morpholinonicotinoyl Chloride
• CAS No.: 313350-36-6
• Molecular Formula: C10H11ClN2O2
• Molecular Weight: 226.663
• Hs Code.: 2934999090
• DSSTox Substance ID: DTXSID20380098
• Wikidata: Q82170157
• Mol file: 313350-36-6.mol

Synonyms:6-Morpholinonicotinoyl Chloride;313350-36-6;6-morpholin-4-ylpyridine-3-carbonyl Chloride;6-(Morpholin-4-yl)pyridine-3-carbonyl chloride;6-(Morpholin-4-yl)nicotinoyl chloride;3-Pyridinecarbonyl chloride, 6-(4-morpholinyl)-;SCHEMBL243892;DTXSID20380098;CUYODHVYKUWKCO-UHFFFAOYSA-N;MFCD02681966;6-morpholin-4-yl-nicotinoyl chloride;AKOS027381795;AS-45769;BL009078;BP-10027;6-morpholinonicotinoyl chloride, AldrichCPR;FT-0621259;6-(4-morpholinyl)-3-pyridinecarbonyl chloride;6-MORPHOLINOPYRIDINE-3-CARBONYL CHLORIDE;A820805

Chemical Property of 6-Morpholinonicotinoyl Chloride

Chemical Property:

• Vapor Pressure: 1.23E-06mmHg at 25°C
• Melting Point: 122-124°C
• Refractive Index: 1.568
• Boiling Point: 400.9 °C at 760 mmHg
• PKA: 2.66±0.10(Predicted)
• Flash Point: 196.3 °C
• PSA: 42.43000
• Density: 1.314 g/cm³
• LogP: 1.36220
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 226.0509053
• Heavy Atom Count: 15
• Complexity: 232

Purity/Quality:

98%Min ^*data from raw suppliers

6-MorpholinonicotinoylChloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COCCN1C2=NC=C(C=C2)C(=O)Cl

Technology Process of 6-Morpholinonicotinoyl Chloride

There total 4 articles about 6-Morpholinonicotinoyl Chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

oxalyl dichloride (79-37-8) + 6-morpholin-4-ylpyridine-3-carboxylic acid (120800-52-4) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 6-morpholinonicotinoyl chloride (313350-36-6)

Guidance literature:

In chloroform;

Reference yield:

6-Chloro-3-pyridinecarboxylic acid (5326-23-8) → 6-morpholinonicotinoyl chloride (313350-36-6)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium isopropylate / dichloromethane

3: sodium hydroxide

4: chloroform

With sodium hydroxide; sodium isopropylate; In dichloromethane; chloroform;

Reference yield:

isopropyl 6-chloronicotinate (313350-11-7) → 6-morpholinonicotinoyl chloride (313350-36-6)

Guidance literature:

Multi-step reaction with 3 steps

2: sodium hydroxide

3: chloroform

With sodium hydroxide; In chloroform;

upstream raw materials:

oxalyl dichloride

6-morpholin-4-ylpyridine-3-carboxylic acid

N,N-dimethyl-formamide

6-Chloro-3-pyridinecarboxylic acid

Downstream raw materials:

[4-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-4-(3,5-di-tert-butyl-4-methoxy-phenylsulfanyl)-piperidin-1-yl]-(6-morpholin-4-yl-pyridin-3-yl)-methanone

N-{(R)-1-[9-((1R,2S,3R,4S)-2,3-dihydroxy-4-propionylaminocyclopentyl)-6-(2,2-diphenylethylamino)-9H-purin-2-yl]pyrrolidin-3-yl}-6-morpholin-4-yl-nicotinamide trifluoroacetate

(4-bromo-2-fluorophenyl)[6-(4-morpholinyl)-3-pyridinyl]methanone

Refernces

• 1、 -. "Amide substituted imidazoquinolines". . . Retrieved 2008/06/13.