methyl 2-(4-chlorophenyl)-2-mercaptoacetate

Base Information

• Chemical Name: methyl 2-(4-chlorophenyl)-2-mercaptoacetate
• CAS No.: 133692-27-0
• Molecular Formula: C₉H₉ClO₂S
• Molecular Weight: 216.688
• Mol file: 133692-27-0.mol

Synonyms:methyl 2-(4-chlorophenyl)-2-mercaptoacetate

Chemical Property of methyl 2-(4-chlorophenyl)-2-mercaptoacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-(4-chlorophenyl)-2-mercaptoacetate

There total 4 articles about methyl 2-(4-chlorophenyl)-2-mercaptoacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 2-bromo-2-(4-chlorophenyl)acetate (24091-92-7) → methyl 2-(4-chlorophenyl)-2-mercaptoacetate (133692-27-0)

Guidance literature:

Multi-step reaction with 2 steps

1: methanol / 4 h / 20 °C

2: sodium methylate / methanol / 5 h / 20 °C / pH 9 - 10 / Inert atmosphere

With sodium methylate; In methanol;

DOI:10.1016/j.bmcl.2018.01.059

Reference yield:

methyl 4-chloromandelate (32174-34-8,63096-36-6,104420-79-3,13305-19-6) → methyl 2-(4-chlorophenyl)-2-mercaptoacetate (133692-27-0)

Guidance literature:

Multi-step reaction with 3 steps

1: phosphorus tribromide / chloroform / 96 h / 20 °C

2: methanol / 4 h / 20 °C

3: sodium methylate / methanol / 5 h / 20 °C / pH 9 - 10 / Inert atmosphere

With sodium methylate; phosphorus tribromide; In methanol; chloroform;

DOI:10.1016/j.bmcl.2018.01.059

Reference yield:

p-chloromandelic acid (7138-34-3,32189-36-9,76496-63-4,492-86-4) → methyl 2-(4-chlorophenyl)-2-mercaptoacetate (133692-27-0)

Guidance literature:

Multi-step reaction with 4 steps

1: sulfuric acid / 60 °C

2: phosphorus tribromide / chloroform / 96 h / 20 °C

3: methanol / 4 h / 20 °C

4: sodium methylate / methanol / 5 h / 20 °C / pH 9 - 10 / Inert atmosphere

With sulfuric acid; sodium methylate; phosphorus tribromide; In methanol; chloroform;

DOI:10.1016/j.bmcl.2018.01.059

upstream raw materials:

methanol

2-(4-chlorophenyl)-2-mercaptoacetic acid

methyl 4-chloromandelate

methyl 2-bromo-2-(4-chlorophenyl)acetate

Downstream raw materials:

(+/-)-cis-5-(4-Chlorophenyl)-3-methyl-2-(3-pyridyl)thiazolidin-4-one

(+/-)-trans-5-(4-chlorophenyl)-3-methyl-2-(3-pyridyl)thiazolidin-4-one

2-(4-chlorophenyl)-2-mercaptoacetic acid

4-(p-chlorophenyl)-1,3,2-oxathiazolylium-5-olate

Refernces

• 1、 Tanabe, Yoo,Yamamoto, Hitomi,Murakami, Masanari,Yanagi, Kazunori,Kubota, Yoshino,et al.. "Synthetic Study of the Highly Potent and Selective Anti-platelet Activating Factor Thiazolidin-4-one Agents and related Compounds". . p. 935 - 948. Retrieved 2007/10/02.