N-methyl-N-(3-phenylpropyl)-1-naphthalenemethanamine

Base Information

• Chemical Name: N-methyl-N-(3-phenylpropyl)-1-naphthalenemethanamine
• CAS No.: 98977-55-0
• Molecular Formula: C₂₁H₂₃N
• Molecular Weight: 289.42
• Mol file: 98977-55-0.mol

Synonyms:N-methyl-N-(3-phenylpropyl)-1-naphthalenemethanamine

Chemical Property of N-methyl-N-(3-phenylpropyl)-1-naphthalenemethanamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-methyl-N-(3-phenylpropyl)-1-naphthalenemethanamine

There total 6 articles about N-methyl-N-(3-phenylpropyl)-1-naphthalenemethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

3-Phenylpropenol (104-54-1) + N-methyl-1-naphthalenemethylamine (14489-75-9) → N-methyl-N-(3-phenylpropyl)-1-naphthalenemethanamine (98977-55-0)

Guidance literature:

With formic acid; chlorine[2-(4,5-dihydro-1H-imidazol-2-yl)-6-methoxypyridine](pentamethylcyclopentadienyl)iridium(III) chloride; In water; at 80 ℃; for 14h; Inert atmosphere; Schlenk technique;

DOI:10.1021/acs.joc.1c01930

Reference yield: 83.0%

naftifine (65472-88-0) → N-methyl-N-(3-phenylpropyl)-1-naphthalenemethanamine (98977-55-0)

Guidance literature:

With tris(triphenylphosphine)rhodium(l) chloride; hydrogen; In toluene; at 70 ℃; for 24h; Inert atmosphere;

DOI:10.1021/ol503748t

Reference yield:

1-Bromo-3-phenylpropane (637-59-2) + N-methyl-1-naphthalenemethylamine (14489-75-9) → N-methyl-N-(3-phenylpropyl)-1-naphthalenemethanamine (98977-55-0)

Guidance literature:

With sodium carbonate; In N,N-dimethyl-formamide; at 70 ℃; for 5h;

DOI:10.1021/jm00151a019

upstream raw materials:

1-Bromo-3-phenylpropane

N-methyl-1-naphthalenemethylamine

1-Chloromethylnaphthalene

naftifine

Refernces

• 1、 -. "ADENYLYL CYCLASE INHIBITORS FOR NEUROPATHIC AND INFLAMMATORY PAIN". Paragraph 0161. . Retrieved 2016/10/11.
• 2、 Stuetz, Anton,Georgopoulos, Apostolos,Granitzer, Waltraud,Petranyi, Gabor,Berney, Daniel. "Synthesis and Structure-Activity Relationships of Naftifine-Related Allylamine Antimycotics". . p. 112 - 125. Retrieved 2007/10/02.