trans-2-methyl-3-phenyloxiranecarboxylic acid

Base Information

• Chemical Name: trans-2-methyl-3-phenyloxiranecarboxylic acid
• CAS No.: 25547-51-7
• Molecular Formula: C₁₀H₁₀O₃
• Molecular Weight: 178.188
• Mol file: 25547-51-7.mol

Synonyms:trans-2-methyl-3-phenyloxiranecarboxylic acid

Chemical Property of trans-2-methyl-3-phenyloxiranecarboxylic acid

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

BMK Glycidic Acid ≥98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: BMK Glycidic Acid (Item No. 19682) is an analytical reference standard categorized as a precursor in the synthesis of phenylacetone (Item Nos. 16103 | 16444). This product is intended for research and forensic applications.

Technology Process of trans-2-methyl-3-phenyloxiranecarboxylic acid

There total 8 articles about trans-2-methyl-3-phenyloxiranecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2-methyl-3-phenylacrylic acid (1895-97-2) → trans-2-methyl-3-phenyloxiranecarboxylic acid (25547-51-7)

Guidance literature:

With Oxone; disodium ethylenediaminetetraacetic acid; sodium hydrogencarbonate; In acetone; at 24 - 27 ℃; for 2.5h;

DOI:10.1021/jo00360a059

Reference yield:

→ α-methyl-trans-α,β-epoxy-β-phenylpropanoic acid (25547-51-7,82812-97-3,82812-98-4)

Guidance literature:

With sodium hydroxide;

DOI:10.1021/ja01641a014

Reference yield:

ethyl ester of the 2-methyl-3-phenyl-2,3-epoxypropionic acid (41232-97-7) → α-methyl-trans-α,β-epoxy-β-phenylpropanoic acid (25547-51-7,82812-97-3,82812-98-4)

Guidance literature:

With potassium hydroxide; In ethanol; at 20 ℃; Yield given;

upstream raw materials:

ethyl ester of the 2-methyl-3-phenyl-2,3-epoxypropionic acid

2-methyl-3-phenylacrylic acid

benzaldehyde

2-Chloro-2-(toluene-4-sulfinyl)-propionic acid

Downstream raw materials:

2-Phenylpropanal

1-phenyl-acetone

(Z)-methyl 2-methyl-3-phenyl-2-oxiranecarboxylate

(E)-methyl 2-methyl-3-phenyl-2-oxiranecarboxylate

Refernces

• 1、 Satoh, Tsuyoshi,Kitoh, Yasushi,Onda, Ken-ichi,Yamakawa, Koji. "Ligand Exchange Reaction of Sulfoxides in Organic Synthesis: A New Method for Generation of Magnesium Enolates of α-Chloro Carboxylic Acids and Their Derivatives". . p. 2331 - 2334. Retrieved 2007/10/02.
• 2、 Kuroyan, R. A.,Markosyan, A. I.,Engoyan, A. P.,Vartanyan, S. A.. "GENERAL RELATIONSHIPS IN THE OPENING OF THE OXIRANE RING DURING CLEAVAGE OF GLYCIDIC ACIDS". . p. 1709 - 1714. Retrieved 2007/10/02.