2,5-DICHLORO-4,6-DIMETHYLNICOTINAMIDE

Base Information

• Chemical Name: 2,5-DICHLORO-4,6-DIMETHYLNICOTINAMIDE
• CAS No.: 175204-44-1
• Molecular Formula: C8H8 Cl2 N2 O
• Molecular Weight: 219.07
• Hs Code.: 2933399090
• Mol file: 175204-44-1.mol

Synonyms:NSC 341974

Chemical Property of 2,5-DICHLORO-4,6-DIMETHYLNICOTINAMIDE

Chemical Property:

• Vapor Pressure: 0.0165mmHg at 25°C
• Melting Point: 172 °C
• Boiling Point: 255.3°Cat760mmHg
• Flash Point: 108.2°C
• PSA: 55.98000
• Density: 1.388g/cm³
• LogP: 2.80440

Purity/Quality:

98%Min ^*data from raw suppliers

2,5-DICHLORO-4,6-DIMETHYLNICOTINAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,5-DICHLORO-4,6-DIMETHYLNICOTINAMIDE

There total 3 articles about 2,5-DICHLORO-4,6-DIMETHYLNICOTINAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

2,5-dichloro-4,6-dimethylpyridine-3-carbonitrile (91591-63-8) → 2,5-dichloro-4,6-dimethylnicotinamide (175204-44-1)

Guidance literature:

With sulfuric acid; Heating;

DOI:10.1023/B:COHC.0000028626.45566.67

Reference yield:

3-Cyano-4,6-dimethyl-2(1H)-pyridon (769-28-8) → 2,5-dichloro-4,6-dimethylnicotinamide (175204-44-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 94 percent / sulfuryl chloride / CCl₄ / 6 h / Heating

2: 76 percent / POCl₃ / Heating

3: 91 percent / aq. H₂SO₄ / Heating

With sulfuryl dichloride; sulfuric acid; trichlorophosphate; In tetrachloromethane;

DOI:10.1023/B:COHC.0000028626.45566.67

Reference yield:

5-chloro-4,6-dimethyl-2-oxo-1,2-dihydropyridine-3-carbonitrile (23819-92-3) → 2,5-dichloro-4,6-dimethylnicotinamide (175204-44-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 76 percent / POCl₃ / Heating

2: 91 percent / aq. H₂SO₄ / Heating

With sulfuric acid; trichlorophosphate;

DOI:10.1023/B:COHC.0000028626.45566.67

upstream raw materials:

2,5-dichloro-4,6-dimethylpyridine-3-carbonitrile

3-Cyano-4,6-dimethyl-2(1H)-pyridon

5-chloro-4,6-dimethyl-2-oxo-1,2-dihydropyridine-3-carbonitrile

Refernces

• 1、 Dyadyuchenko,Strelkov,Mikhailichenko,Zaplishny. "Synthesis of some halogen- and nitro-substituted nicotinic acids and their fragmentation under electron impact". . p. 308 - 314. Retrieved 2007/10/03.