3,5-Dichloro-4-hydrazinylpyridine

Base Information

• Chemical Name: 3,5-Dichloro-4-hydrazinylpyridine
• CAS No.: 153708-69-1
• Molecular Formula: C5H5Cl2N3
• Molecular Weight: 178.021
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID00353144
• Wikidata: Q82130597
• Mol file: 153708-69-1.mol

Synonyms:153708-69-1;3,5-dichloro-4-hydrazinylpyridine;1-(3,5-dichloro-4-pyridyl)hydrazine;(3,5-dichloropyridin-4-yl)hydrazine;1-(3,5-Dichloropyridin-4-yl)hydrazine;SCHEMBL1665457;DTXSID00353144;3,5-Dichloro-4-hydrazinopyridine;MFCD00174279;AKOS006223882;SB52597;BS-25242;CS-0091249;FT-0605591

Chemical Property of 3,5-Dichloro-4-hydrazinylpyridine

Chemical Property:

• Vapor Pressure: 0.00978mmHg at 25°C
• Melting Point: 113-115°C
• Boiling Point: 264.3°Cat760mmHg
• PKA: 3.10±0.33(Predicted)
• Flash Point: 113.6°C
• PSA: 50.94000
• Density: 1.572g/cm³
• LogP: 2.44730
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 176.9860526
• Heavy Atom Count: 10
• Complexity: 101

Purity/Quality:

98%min ^*data from raw suppliers

1-(3,5-Dichloro-4-pyridyl)hydrazine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(C(=C(C=N1)Cl)NN)Cl

Technology Process of 3,5-Dichloro-4-hydrazinylpyridine

There total 2 articles about 3,5-Dichloro-4-hydrazinylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

3,5-dichloro-4-iodopyridine (343781-41-9) → (3,5-dichloropyridin-4-yl)hydrazine (153708-69-1)

Guidance literature:

With hydrazine hydrate; In ethanol; at 90 ℃; for 16h;

DOI:10.1021/jm2012326

Reference yield:

3,4,5-trichloropyridine (33216-52-3) → (3,5-dichloropyridin-4-yl)hydrazine (153708-69-1)

Guidance literature:

Reference yield: 99.0%

(3,5-dichloropyridin-4-yl)hydrazine (153708-69-1) + 3-phenyl-propionaldehyde (104-53-0) → 3,5-dichloro-4-(2-(3-phenylpropyl)hydrazin-1-yl)pyridine (1370287-74-3)

Guidance literature:

(3,5-dichloropyridin-4-yl)hydrazine; 3-phenyl-propionaldehyde; With acetic acid; In dichloromethane; at 20 ℃; for 0.5h;

With sodium cyanoborohydride; In dichloromethane; at 20 ℃; for 0.5h;

upstream raw materials:

3,4,5-trichloropyridine

3,5-dichloro-4-iodopyridine

Downstream raw materials:

1-[1-(3,5-dichloro-pyridin-4-yl)-5-methyl-1H-pyrazol-4-yl]-3-[4-(3,5-difluoro-phenyl)-piperazin-1-yl]-propan-1-one

N-benzyl-2-(3,5-dichloropyridin-4-yl)hydrazinecarboxamide

N'-(3,5-dichloropyridin-4-yl)-N-methyl-3-phenylpropanehydrazide

2-(4-chlorophenyl)-N'-(3,5-dichloropyridin-4-yl)acetohydrazide

Refernces

• 1、 -. "Novel Hydrazine Derivatives and Uses Thereof". Paragraph 0104-0105; 0137-0138. . Retrieved 2017/10/28.
• 2、 -. "Pyrazole derivatives". . . Retrieved 2019/07/22.