DL-ALPHA-METHYLTRYPTOPHAN METHYL ESTER HYDROCHLORIDE

Base Information

• Chemical Name: DL-ALPHA-METHYLTRYPTOPHAN METHYL ESTER HYDROCHLORIDE
• CAS No.: 114524-80-0
• Molecular Formula: C13H16N2O2
• Molecular Weight: 232.282
• Hs Code.: 2933998090
• Mol file: 114524-80-0.mol

Synonyms:DL-Tryptophan,α-methyl-, methyl ester;2-Amino-3-(1H-indol-3-yl)-2-methylpropionic acid methyl ester;α-Methyl-DL-tryptophan methylester;

Chemical Property of DL-ALPHA-METHYLTRYPTOPHAN METHYL ESTER HYDROCHLORIDE

Chemical Property:

• Appearance/Colour: white crystalline solid
• Melting Point: 139-142 °C
• Boiling Point: 394.3 °C at 760 mmHg
• PKA: 17.21±0.30(Predicted)
• Flash Point: 192.3 °C
• PSA: 68.11000
• Density: 1.213 g/cm³
• LogP: 2.30110
• Storage Temp.: 2-8°C
• Solubility.: Chloroform, DMSO, Methanol

Purity/Quality:

98%Min ^*data from raw suppliers

DL-alpha-Methyltryptophan methyl ester hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: R34:Causes burns.
• Safety Statements: S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.; S36/37/39:Wear suitabl

MSDS Files:

SDS file from LookChem

Useful:

• Uses: A tryptophan derivative as tachykinin antagonist A tryptophan derivative as tachykinin antagonist.

Technology Process of DL-ALPHA-METHYLTRYPTOPHAN METHYL ESTER HYDROCHLORIDE

There total 3 articles about DL-ALPHA-METHYLTRYPTOPHAN METHYL ESTER HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(1H-Indol-3-yl)-2-methyl-2-{[1-phenyl-meth-(E)-ylidene]-amino}-propionic acid methyl ester (74761-92-5) → methyl 2-(indol-3-ylmethyl)-2-aminopropionate (114524-80-0)

Guidance literature:

With hydrogenchloride; for 1h; Yield given; Ambient temperature;

Reference yield:

Nb-benzylidene-L-tryptophan methyl ester (19779-75-0,67628-15-3) → methyl 2-(indol-3-ylmethyl)-2-aminopropionate (114524-80-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) LDA / 1.) THF, -78 deg C, 0.5 h, 2.) THF, RT, overnight

2: 1N aq. HCl / 1 h / Ambient temperature

With hydrogenchloride; lithium diisopropyl amide;

Reference yield:

→ methyl 2-(indol-3-ylmethyl)-2-aminopropionate (114524-80-0)

Guidance literature:

upstream raw materials:

3-(1H-Indol-3-yl)-2-methyl-2-{[1-phenyl-meth-(E)-ylidene]-amino}-propionic acid methyl ester

N_b-benzylidene-L-tryptophan methyl ester

Downstream raw materials:

2-(5-Ethynyl-2-trifluoromethoxy-benzoylamino)-3-(1H-indol-3-yl)-2-methyl-propionic acid methyl ester

L-α-methyl-tryptophan methyl ester

(S)-α-methyltryptophan

α-methyl-(R)-tryptophan methyl ester

Refernces

• 1、 Brana, Miguel F.,Garrido, Mercedes,Rodriguez, Maria L. Lopez,Morcillo, M. Jose. "α-ALKYLTRYPTOPHANS". . p. 2139 - 2151. Retrieved 2007/10/02.