3-(STYRYLTHIO)PROPANOIC ACID

Base Information

• Chemical Name: 3-(STYRYLTHIO)PROPANOIC ACID
• CAS No.: 175205-21-7
• Molecular Formula: C₁₁H₁₂O₂S
• Molecular Weight: 208.281
• Hs Code.: 2930909090
• Mol file: 175205-21-7.mol

Synonyms:3-(STYRYLTHIO)PROPANOIC ACID;(Z)-STYRYLTHIOPROPIONIC ACID

Chemical Property of 3-(STYRYLTHIO)PROPANOIC ACID

Chemical Property:

• Vapor Pressure: 6.56E-07mmHg at 25°C
• Melting Point: 117℃
• Boiling Point: 393.9°Cat760mmHg
• Flash Point: 192°C
• PSA: 62.60000
• Density: 1.21g/cm³
• LogP: 2.86520

Purity/Quality:

98%min ^*data from raw suppliers

3-(Styrylthio)propanoic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R36/37/38:Irritating to eyes, respiratory system and skin.
• Hazard Codes: Xn
• Statements: 22-43
• Safety Statements: 36/37

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(STYRYLTHIO)PROPANOIC ACID

There total 4 articles about 3-(STYRYLTHIO)PROPANOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

(Z)-β-bromostyrene (588-73-8,1340-14-3) + 3-mercaptopropionic acid (107-96-0) → (Z)-3-(styrylthio)propanoic acid (175205-21-7)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; In toluene; at 90 ℃; for 12h;

DOI:10.1016/j.bmc.2020.115990

Reference yield: 30.0%

bromostyrene (103-64-0,1340-14-3) + 3-mercaptopropionic acid (107-96-0) → (E)-3-(styrylthio)propanoic acid (175205-21-7)

Guidance literature:

With triethylamine; In tetrahydrofuran; for 1h; Reflux;

DOI:10.1016/j.bmc.2020.115990

Reference yield:

(E)-3-phenylacrylic acid (140-10-3) → (Z)-3-(styrylthio)propanoic acid (175205-21-7)

Guidance literature:

Multi-step reaction with 3 steps

1: bromine / chloroform / 0.5 h / Reflux

2: potassium carbonate; sodium sulfate / acetone / 1 h / 80 °C / Molecular sieve

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / toluene / 12 h / 90 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; bromine; potassium carbonate; sodium sulfate; triethylamine; In chloroform; acetone; toluene;

DOI:10.1016/j.bmc.2020.115990

upstream raw materials:

bromostyrene

3-mercaptopropionic acid

(Z)-β-bromostyrene

(E)-3-phenylacrylic acid

Refernces