3-BROMOTHIOPHENE-2-CARBOXAMIDE

Base Information

• Chemical Name: 3-BROMOTHIOPHENE-2-CARBOXAMIDE
• CAS No.: 78031-18-2
• Molecular Formula: C₅H₄BrNOS
• Molecular Weight: 206.063
• Hs Code.: 29349990
• Mol file: 78031-18-2.mol

Synonyms:3-Bromo-2-thiophenecarboxamide;

Chemical Property of 3-BROMOTHIOPHENE-2-CARBOXAMIDE

Chemical Property:

• Vapor Pressure: 0.0009mmHg at 25°C
• Melting Point: 77-78 °C
• Refractive Index: 1.645
• Boiling Point: 318 °C at 760 mmHg
• Flash Point: 146.1 °C
• PSA: 71.33000
• Density: 1.81 g/cm³
• LogP: 2.30980
• Storage Temp.: 2-8°C
• Water Solubility.: Insoluble in water.

Purity/Quality:

99% ^*data from raw suppliers

3-Bromothiophene-2-carboxamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-Bromothiophene-2-carboxamide is used in Stille cross-coupling conditions were used to couple the resin-bound peptide.

Technology Process of 3-BROMOTHIOPHENE-2-CARBOXAMIDE

There total 7 articles about 3-BROMOTHIOPHENE-2-CARBOXAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-bromo-thiophene-2-carbonyl chloride (25796-68-3) → 3-bromo-2-carboxamidothiophene (78031-18-2)

Guidance literature:

With ammonia; In diethyl ether; at -10 ℃;

DOI:10.1002/oms.1210151207

Reference yield:

Methyl 3-aminothiophene-2-carboxylate (22288-78-4) → 3-bromo-2-carboxamidothiophene (78031-18-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 59 percent / hydrazine hydrate / butan-1-ol / 4 h / Heating

2: 8 percent / conc. HCl, sodium nitrite / H₂O / 0.08 h

3: pyridinium hydrobromide perbromide / 4 h / Heating

With hydrogenchloride; pyridinium hydrobromide perbromide; hydrazine hydrate; sodium nitrite; In water; butan-1-ol;

Reference yield:

3-aminothiophene-2-carbohydrazide (137844-98-5) → 3-bromo-2-carboxamidothiophene (78031-18-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 8 percent / conc. HCl, sodium nitrite / H₂O / 0.08 h

2: pyridinium hydrobromide perbromide / 4 h / Heating

With hydrogenchloride; pyridinium hydrobromide perbromide; sodium nitrite; In water;

upstream raw materials:

3-bromo-thiophene-2-carbonitrile

3-bromo-thiophene-2-carbonyl chloride

acetic acid

thieno<3,2-d>-1,2,3-triazin-4(3H)-one

Refernces

• 1、 Occhipinti, Salvatore,Alberghina, Gaetano,Fisichella, Salvatore,Puglisi, Orazio,Ceraulo, Leopoldo. "The Fragmentation of 5- and 3-Substituted Thiophene-2-carboxamides Under Electron Impact". . p. 632 - 636. Retrieved 2007/10/02.