3-n-propyl-1,4-diphenylisoquinoline

Base Information

• Chemical Name: 3-n-propyl-1,4-diphenylisoquinoline
• CAS No.: 75097-27-7
• Molecular Formula: C₂₄H₂₁N
• Molecular Weight: 323.437
• Mol file: 75097-27-7.mol

Synonyms:3-n-propyl-1,4-diphenylisoquinoline

Chemical Property of 3-n-propyl-1,4-diphenylisoquinoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-n-propyl-1,4-diphenylisoquinoline

There total 6 articles about 3-n-propyl-1,4-diphenylisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

N-butylamine (109-73-9,85404-21-3) + o-dibenzoylbenzene (1159-86-0) → 3-n-propyl-1,4-diphenylisoquinoline (75097-27-7)

Guidance literature:

With potassium tert-butylate; In tert-butyl alcohol; for 72h;

Reference yield: 55.0%

1-phenyl-1-pentyne (4250-81-1) + Benzophenone oxime (574-66-3) → 1,3-diphenyl-4-propylisoquinoline (1295521-98-0) + 3-n-propyl-1,4-diphenylisoquinoline (75097-27-7)

Guidance literature:

With dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; cesium acetate; In methanol; at 60 ℃; for 16h; regioselective reaction; Inert atmosphere;

DOI:10.1002/adsc.201000887

Reference yield: 26.0%

N-tert-butylsulfinyl ketoimine (891782-22-2) + 1-phenyl-1-pentyne (4250-81-1) → 1,3-diphenyl-4-propylisoquinoline (1295521-98-0) + 3-n-propyl-1,4-diphenylisoquinoline (75097-27-7)

Guidance literature:

N-tert-butylsulfinyl ketoimine; 1-phenyl-1-pentyne; With CoCp*(CO)I₂; acetic acid; silver(I) triflimide; In 1,2-dichloro-ethane; at 120 ℃; for 18h; Inert atmosphere; Sealed tube;

With sodium tetrahydroborate; In methanol; at 20 ℃; for 0.5h; Overall yield = 69 %;

DOI:10.1016/S1872-2067(16)62491-9

upstream raw materials:

N-butylamine

o-dibenzoylbenzene

benzophenone

1-phenyl-1-pentyne

Refernces

• 1、 Zhang, Xingping,Chen, Dan,Zhao, Miao,Zhao, Jing,Jia, Aiqun,Li, Xingwei. "Synthesis of isoquinolines via rhodium(III)-catalyzed dehydrative C-C and C-N coupling between oximines and alkynes". . p. 719 - 723. Retrieved 2011/05/08.
• 2、 Mataka, Shuntaro,Takahashi, Kazufumi,Tsuda, Yuhsuke,Tashiro, Masashi. "PREPARATION OF 1,4-DIPHENYL-3-SUBSTITUTED ISOQUINOLINES". . p. 789 - 792. Retrieved 2007/10/02.