C₄₄H₅₆O₈Si

Base Information

• Chemical Name: C₄₄H₅₆O₈Si
• CAS No.: 1319715-12-2
• Molecular Formula: C₄₄H₅₆O₈Si
• Molecular Weight: 741.009
• Mol file: 1319715-12-2.mol

Synonyms:C₄₄H₅₆O₈Si

Chemical Property of C₄₄H₅₆O₈Si

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₄H₅₆O₈Si

There total 10 articles about C₄₄H₅₆O₈Si which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C34H42O6Si (1319715-13-3) + 1-bromo-2-(1,1-dimethoxyethyl)benzene (120254-80-0) → C44H56O8Si (1319715-12-2)

Guidance literature:

1-bromo-2-(1,1-dimethoxyethyl)benzene; With n-butyllithium; In tetrahydrofuran; at 20 ℃; for 0.25h; Inert atmosphere;

C₃₄H₄₂O₆Si; In tetrahydrofuran; at 20 ℃; for 0.166667h; Inert atmosphere;

With ammonium chloride; In tetrahydrofuran; water; Saturated solution;

DOI:10.1021/ol2015847

Reference yield:

1,8-dihydroxynaphthalene (569-42-6) → C44H56O8Si (1319715-12-2)

Guidance literature:

Multi-step reaction with 7 steps

1.1: potassium carbonate / acetone / 10 h / 18 °C

2.1: N-Bromosuccinimide / acetonitrile / 23 h

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1.33 h / 0 °C

3.2: 6 h / 0 °C

4.1: n-butyllithium / tetrahydrofuran; hexane / 0.17 h / -78 °C / Inert atmosphere

4.2: -78 - 25 °C

4.3: 20 °C / Saturated solution

5.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 20 °C

6.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,4-dioxane; water / 70 °C / Inert atmosphere

7.1: n-butyllithium / tetrahydrofuran / 0.25 h / 20 °C / Inert atmosphere

7.2: 0.17 h / 20 °C / Inert atmosphere

7.3: Saturated solution

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; sodium hydride; sodium carbonate; potassium carbonate; In tetrahydrofuran; 1,4-dioxane; hexane; water; N,N-dimethyl-formamide; acetone; acetonitrile; mineral oil; 6.1: Suzuki-Miyaura coupling;

DOI:10.1021/ol2015847

Reference yield:

4-bromo-8-methoxynaphthalen-1-ol (184221-86-1) → C44H56O8Si (1319715-12-2)

Guidance literature:

Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1.33 h / 0 °C

1.2: 6 h / 0 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.17 h / -78 °C / Inert atmosphere

2.2: -78 - 25 °C

2.3: 20 °C / Saturated solution

3.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 20 °C

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,4-dioxane; water / 70 °C / Inert atmosphere

5.1: n-butyllithium / tetrahydrofuran / 0.25 h / 20 °C / Inert atmosphere

5.2: 0.17 h / 20 °C / Inert atmosphere

5.3: Saturated solution

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; sodium hydride; sodium carbonate; In tetrahydrofuran; 1,4-dioxane; hexane; water; N,N-dimethyl-formamide; mineral oil; 4.1: Suzuki-Miyaura coupling;

DOI:10.1021/ol2015847

upstream raw materials:

C₁₃H₁₃BrO₃

C₁₄H₁₄O₄

C₃₄H₄₂O₆Si

1-bromo-2-(1,1-dimethoxyethyl)benzene

Refernces