2-PYRIDIN-3-YLANILINE

Base Information

• Chemical Name: 2-PYRIDIN-3-YLANILINE
• CAS No.: 177202-83-4
• Molecular Formula: C11H10N2
• Molecular Weight: 170.214
• Hs Code.: 2933399090
• Mol file: 177202-83-4.mol

Synonyms:2-PYRIDIN-3-YLANILINE;2-(Pyridin-3-yl)aniline 95%;2-pyridin-3-ylphenylaMine;3-(2-Aminophenyl)pyridine

Chemical Property of 2-PYRIDIN-3-YLANILINE

Chemical Property:

• Vapor Pressure: 0.000174mmHg at 25°C
• Melting Point: 214-216 °C (decomp)(Solv: water (7732-18-5); ethanol (64-17-5))
• Refractive Index: 1.625
• Boiling Point: 329.8 °C at 760 mmHg
• PKA: 4.55±0.12(Predicted)
• Flash Point: 179.5 °C
• PSA: 38.91000
• Density: 1.133 g/cm³
• LogP: 2.91200
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

99% ^*data from raw suppliers

2-(Pyridin-3-yl)aniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-PYRIDIN-3-YLANILINE

There total 14 articles about 2-PYRIDIN-3-YLANILINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

3-pyridylboronic acid (1692-25-7) + 2-bromoaniline (615-36-1) → 2-(pyridin-3-yl)phenylamine (177202-83-4)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; In 1,4-dioxane; water; at 80 ℃; for 2.5h; Inert atmosphere;

DOI:10.1021/ol2008268

Reference yield: 99.0%

3-(tributylstannyl)pyridine (59020-10-9) + 2-bromoaniline (615-36-1) → 2-(pyridin-3-yl)phenylamine (177202-83-4)

Guidance literature:

With copper(l) iodide; C₃₇H₅₁ClFeNPPd; cesium fluoride; In N,N-dimethyl-formamide; at 80 ℃; for 12h; Inert atmosphere;

DOI:10.1016/j.tet.2012.10.080

Reference yield: 94.6%

3-(2-nitro-phenyl)-pyridine (4253-80-9) → 2-(pyridin-3-yl)phenylamine (177202-83-4)

Guidance literature:

With hydrogen; platinum(IV) oxide; In methanol; for 3.5h; under 2585.81 Torr;

upstream raw materials:

3-(2-nitro-phenyl)-pyridine

3-Bromopyridine

2-anilineboronic acid pinacol ester

pyridine

Downstream raw materials:

benzo[f][1,7]naphthyridin-5(6H)-one

3-phenylpyridine

5-phenylbenzo[h]isoquinoline

5-phenylbenzo[f]quinoline

Refernces

• 1、 Jin, Zhong,Chu, Ling,Chen, Yan-Qiao,Yu, Jin-Quan. "Pd-Catalyzed Remote Meta-C-H Functionalization of Phenylacetic Acids Using a Pyridine Template". . p. 425 - 428. Retrieved 2018.
• 2、 Chatterjee, Tanmay,Choi, Myung Gil,Kim, Jun,Chang, Suk-Kyu,Cho, Eun Jin. "Visible-light-induced regioselective synthesis of polyheteroaromatic compounds". supporting information. p. 4203 - 4206. Retrieved 2016/03/19.