1-(TERT-BUTOXYCARBONYL)-6-CHLORO-1H-INDOL-2-YLBORONIC ACID

Base Information

• Chemical Name: 1-(TERT-BUTOXYCARBONYL)-6-CHLORO-1H-INDOL-2-YLBORONIC ACID
• CAS No.: 352359-22-9
• Molecular Formula: C13H15BClNO4
• Molecular Weight: 295.53
• Hs Code.: 2933990090
• Mol file: 352359-22-9.mol

Synonyms:1-BOC-6-CHLORO-2-INDOLEBORONIC ACID;1-BOC-6-CHLOROINDOLE-2-BORONIC ACID;1-(TERT-BUTOXYCARBONYL)-6-CHLORO-1H-INDOL-2-YLBORONIC ACID;6-Chloroindole-2-boronic acid, N-BOC protected;6-Chloroindole-2-boronic acid, N-BOC protected 98%;N-BOC-6-CHLOROINDOLE-2-BORONIC ACID;1H-Indole-1-carboxylic acid, 2-borono-6-chloro-, 1-(1,1-dimethylethyl) ester;1-(tert-butoxycarbonyl)-6-chloro-1H-indol-2-yl-2-boronic acid

Chemical Property of 1-(TERT-BUTOXYCARBONYL)-6-CHLORO-1H-INDOL-2-YLBORONIC ACID

Chemical Property:

• Vapor Pressure: 1.09E-09mmHg at 25°C
• Melting Point: 110-113
• Refractive Index: 1.559
• Boiling Point: 471.4 °C at 760 mmHg
• Flash Point: 238.9 °C
• PSA: 71.69000
• Density: 1.27 g/cm³
• LogP: 1.75770
• Storage Temp.: Keep Cold

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-BOC-6-chloroindole-2-boronicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(TERT-BUTOXYCARBONYL)-6-CHLORO-1H-INDOL-2-YLBORONIC ACID

There total 5 articles about 1-(TERT-BUTOXYCARBONYL)-6-CHLORO-1H-INDOL-2-YLBORONIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.5%

6-chloroindole-1-carboxylic acid tert-butyl ester (323580-68-3) + Triisopropyl borate (5419-55-6) + water (7732-18-5) → {1-[(tert-butoxy)carbonyl]-6-chloro-1H-indol-2-yl}boronic acid (352359-22-9)

Guidance literature:

6-chloroindole-1-carboxylic acid tert-butyl ester; Triisopropyl borate; With lithium diisopropyl amide; In tetrahydrofuran; at 5 ℃; for 0.333333h;

water; With hydrogenchloride; In tetrahydrofuran;

Reference yield: 27.0%

→ {1-[(tert-butoxy)carbonyl]-6-chloro-1H-indol-2-yl}boronic acid (352359-22-9)

Guidance literature:

Reference yield:

6-chloroindole-1-carboxylic acid tert-butyl ester (323580-68-3) → {1-[(tert-butoxy)carbonyl]-6-chloro-1H-indol-2-yl}boronic acid (352359-22-9)

Guidance literature:

6-chloroindole-1-carboxylic acid tert-butyl ester; With Triisopropyl borate; lithium diisopropyl amide; In tetrahydrofuran; at 0 ℃; for 1.5h;

With hydrogenchloride; In tetrahydrofuran; water;

upstream raw materials:

6-chloroindole-1-carboxylic acid tert-butyl ester

Triisopropyl borate

water

6-chloroindole

Downstream raw materials:

2-(5-benzyloxy-pyridin-3-yl)-6-chloro-1-methyl-1H-indole

tert-butyl 6-chloro-2-(4-(4-cyanophenoxy)phenyl)-1H-indole-1-carboxylate

6-chloro-2-(4-trifluoromethyl-benzyl)-indole-1-carboxylic acid tert-butyl ester

6-chloro-2-(5-hydroxy-pyridin-3-yl)-indole-1-carboxylic acid tert-butyl ester

Refernces

• 1、 -. "PYRIDINE AND PYRAZINE DERIVATIVES AS MNK KINASE INHIBITORS". Page/Page column 149-150. . Retrieved 2008/06/13.
• 2、 -. "SUBSTITUTED PYRAZOLES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE". Page/Page column 34. . Retrieved 2008/06/13.