3-AMINO-N-ISOPROPYLBENZENESULFONAMIDE

Base Information

• Chemical Name: 3-AMINO-N-ISOPROPYLBENZENESULFONAMIDE
• CAS No.: 118837-66-4
• Molecular Formula: C9H14N2O2S
• Molecular Weight: 214.288
• Hs Code.: 2935009090
• Mol file: 118837-66-4.mol

Synonyms:3-Amino-N-isopropylbenzenesulfonamide;

Chemical Property of 3-AMINO-N-ISOPROPYLBENZENESULFONAMIDE

Chemical Property:

• Refractive Index: 1.558
• Boiling Point: 384 °C at 760 mmHg
• Flash Point: 186 °C
• PSA: 80.57000
• Density: 1.219 g/cm³
• LogP: 3.00840
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

N-Isopropyl3-aminobenzenesulfonamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-AMINO-N-ISOPROPYLBENZENESULFONAMIDE

There total 1 articles about 3-AMINO-N-ISOPROPYLBENZENESULFONAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

N-methylethyl-3-nitrobenzenesulfonamide (28860-10-8) → 3-amino-N-(methylethyl)benzenesulfonamide (118837-66-4)

Guidance literature:

With sodium tetrahydroborate; nickel(II) chloride hexahydrate; In tetrahydrofuran; methanol; at 0 ℃; for 0.333333h;

DOI:10.1016/j.bmc.2010.06.038

Reference yield: 91.0%

2,4-dichloro-5,7-dihydrofuro[3,4-d]pyrimidine (848398-41-4) + 3-amino-N-(methylethyl)benzenesulfonamide (118837-66-4) → 2-chloro-N4-(3-[N-(1-methylethyl)sulfamoyl]phenyl)-5,7-dihydrofuro[3,4-d]pyrimidine-4-amine

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In isopropyl alcohol; at 100 ℃; for 18h;

Reference yield: 88.0%

3-amino-N-(methylethyl)benzenesulfonamide (118837-66-4) + 2,4,5-trichloropyrimidine (5750-76-5) → 2,5-dichloro-N4-(3-[N-(methylethyl)sulfamoyl]phenyl)pyrimidin-4-amine

Guidance literature:

In methanol; water; at 45 ℃; for 22.5h;

upstream raw materials:

N-methylethyl-3-nitrobenzenesulfonamide

Downstream raw materials:

C₁₉H₁₇ClN₂O₄S

Refernces

• 1、 -. "POTENT DUAL BRD4-KINASE INHIBITORS AS CANCER THERAPEUTICS". Page/Page column 122; 124. . Retrieved 2016/04/26.