5-NITRO-1,3-THIAZOLE 96

Base Information

• Chemical Name: 5-NITRO-1,3-THIAZOLE 96
• CAS No.: 14527-46-9
• Molecular Formula: C₃H₂N₂O₂S
• Molecular Weight: 130.127
• Hs Code.: 2934100090
• Mol file: 14527-46-9.mol

Synonyms:5-Nitrothiazole;

Chemical Property of 5-NITRO-1,3-THIAZOLE 96

Chemical Property:

• Vapor Pressure: 0.0342mmHg at 25°C
• Melting Point: 55-57
• Refractive Index: 1.614
• Boiling Point: 250.5 °C at 760 mmHg
• PKA: -0.96±0.10(Predicted)
• Flash Point: 105.3 °C
• PSA: 86.95000
• Density: 1.549 g/cm³
• LogP: 1.57450
• Storage Temp.: Keep Cold

Purity/Quality:

98%min ^*data from raw suppliers

5-Nitrothiazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-NITRO-1,3-THIAZOLE 96

There total 4 articles about 5-NITRO-1,3-THIAZOLE 96 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

2-amino-5-nitro-1,3-thiazole (121-66-4,176384-36-4,8023-00-5) → 5-nitrothiazole (14527-46-9)

Guidance literature:

With tetrahydrofuran; oxygen; nitrogen(II) oxide; for 8h; Ambient temperature;

DOI:10.1248/cpb.45.1547

Reference yield:

2-bromo-5-nitro-1,3-thiazole (3034-48-8) → 5-nitrothiazole (14527-46-9)

Guidance literature:

With copper; acetic acid;

DOI:10.1002/hlca.19550380612

Reference yield:

C16H36N(1+)*C3H3N2O2S(1-) → 5-nitrothiazole (14527-46-9) + tetrabutylammonium borohydride

Guidance literature:

With borane; In toluene; at 21 ℃; Equilibrium constant; var. solvents;

upstream raw materials:

2-bromo-5-nitro-1,3-thiazole

5-nitro-2-thiazole 2-carboxylic acid

2-amino-5-nitro-1,3-thiazole

Downstream raw materials:

N-(thiazol-5-yl)acetamide

Refernces

• 1、 Itoh, Takashi,Matsuya, Yuji,Nagata, Kazuhiro,Ohsawa, Akio. "Deamination of 2-aminothiazoles and 3-amino-1,2,4-triazines with nitric oxide in the presence of a catalytic amount of oxygen". . p. 1547 - 1549. Retrieved 1997.
• 2、 Forlani, Luciano,Ferrara, Antonio,Lugli, Andrea,Todesco, Paolo E.. "Formation of ?-Anionic Complexes in Reactions between 5-Nitrothiazole, 6-Nitrobenzothiazole and Tetrabutylammonium Borohydride". . p. 1703 - 1708. Retrieved 2007/10/02.