3-(TETRAHYDRO-2H-PYRAN-2-YLOXY)PHENYLBORONIC ACID PINACOL ESTER

Base Information

• Chemical Name: 3-(TETRAHYDRO-2H-PYRAN-2-YLOXY)PHENYLBORONIC ACID PINACOL ESTER
• CAS No.: 850568-69-3
• Molecular Formula: C17H25BO4
• Molecular Weight: 304.194
• Hs Code.: 2932999099
• Mol file: 850568-69-3.mol

Synonyms:3-(2-Tetrahydro-2H-pyran-2-yloxy)benzeneboronic acid, pinacol ester;3-(Tetrahydro-2H-pyran-2-yloxy)phenylboronic acid pinacol ester;3-Thpo-phenylboronic acid, pinacol ester;

Chemical Property of 3-(TETRAHYDRO-2H-PYRAN-2-YLOXY)PHENYLBORONIC ACID PINACOL ESTER

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 44-48 °C
• Refractive Index: 1.511
• Boiling Point: 425.232 °C at 760 mmHg
• Flash Point: 210.973 °C
• PSA: 36.92000
• Density: 1.085 g/cm³
• LogP: 2.89120
• Storage Temp.: Keep Cold

Purity/Quality:

98% ^*data from raw suppliers

3-(Tetrahydro-2H-pyran-2-yloxy)[henylboronicAcidPinacolEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(TETRAHYDRO-2H-PYRAN-2-YLOXY)PHENYLBORONIC ACID PINACOL ESTER

There total 1 articles about 3-(TETRAHYDRO-2H-PYRAN-2-YLOXY)PHENYLBORONIC ACID PINACOL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-phenoxytetrahydropyran (4203-50-3) + 2-Isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (61676-62-8) → 2-{[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]oxy}tetrahydro-2H-pyran (850568-69-3)

Guidance literature:

2-phenoxytetrahydropyran; With n-butyllithium; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 1.5h; Inert atmosphere;

2-Isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 16h; Inert atmosphere;

DOI:10.1002/chem.202001450

Reference yield:

6-bromo-4-nitro-2-(tetrahydro-2H-pyran-2-yl)-2H-indazole (1198409-38-9) + 2-{[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]oxy}tetrahydro-2H-pyran (850568-69-3) → 4-nitro-2-(tetrahydro-2H-pyran-2-yl)-6-[3-(tetrahydro-2H-pyran-2-yloxy)phenyl]-2H-indazole (1198802-79-7)

Guidance literature:

With sodium hydrogencarbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In water; isopropyl alcohol; at 150 ℃; for 0.166667h; Microwave irradiation;

Reference yield:

2-{[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]oxy}tetrahydro-2H-pyran (850568-69-3) + ((5-chloro-2'-(prop-1-yn-1-yl)-[1,1'-biphenyl]-2-yl)ethynyl)triisopropylsilane → C37H44O2Si

Guidance literature:

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; palladium diacetate; In water; toluene; at 100 ℃; for 2h; Inert atmosphere;

DOI:10.1002/chem.202001450

upstream raw materials:

2-phenoxytetrahydropyran

2-Isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Downstream raw materials:

4-nitro-2-(tetrahydro-2H-pyran-2-yl)-6-[3-(tetrahydro-2H-pyran-2-yloxy)phenyl]-2H-indazole

Refernces