O-Methyl Ether OlMesartan Acid

Base Information

• Chemical Name: O-Methyl Ether OlMesartan Acid
• CAS No.: 1039762-40-7
• Molecular Formula: C₂₅H₂₈N₆O₃
• Molecular Weight: 460.536
• Mol file: 1039762-40-7.mol

Synonyms:4-(1-methoxy-1-methylethyl)-2-propyl-1-{4-(2-tetrazol-5-yl) phenyl}phenylmethylimidazole-5-carboxylic acid

Chemical Property of O-Methyl Ether OlMesartan Acid

Chemical Property:

• Melting Point: >155°C (dec.)
• Storage Temp.: Refrigerator
• Solubility.: DMSO, Methanol

Purity/Quality:

99% ^*data from raw suppliers

O-MethylEtherOlmesartanAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: O-Methyl Ether Olmesartan Acid is an impurity of Olmesartan Acid (O550001), an detritylated derivative of of Olmesartan Medoxomil (O550000), an angiotensin II receptor antagonist. O-Methyl Ether Olmesartan Acid is an impurity of Olmesartan Acid (O550001), an detritylated derivative of Olmesartan Medoxomil (O550000), an angiotensin II receptor antagonist.

Technology Process of O-Methyl Ether OlMesartan Acid

There total 7 articles about O-Methyl Ether OlMesartan Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

ethyl-4-(1-methoxy-1-methylethyl)-2-propyl-1-{4-(2-trityltetrazol-5-yl)phenyl}phenylmethylimidazole-5-carboxylate (1039762-39-4) → 4-(1-methoxy-1-methylethyl)-2-propyl-1-{4-(2-tetrazol-5-yl) phenyl}phenylmethylimidazole-5-carboxylic acid (1039762-40-7)

Guidance literature:

With sodium hydroxide; In methanol; for 16h; Heating;

DOI:10.1002/jhet.5570450342

Reference yield: 85.0%

methanol (67-56-1) + olmesartan medoxomil (144689-63-4) → 4-(1-methoxy-1-methylethyl)-2-propyl-1-{4-(2-tetrazol-5-yl) phenyl}phenylmethylimidazole-5-carboxylic acid (1039762-40-7)

Guidance literature:

for 24h; Reflux;

Reference yield: 82.0%

methanol (67-56-1) + olmesartan → 4-(1-methoxy-1-methylethyl)-2-propyl-1-{4-(2-tetrazol-5-yl) phenyl}phenylmethylimidazole-5-carboxylic acid (1039762-40-7)

Guidance literature:

for 24h; Reflux;

upstream raw materials:

ethyl-4-(1-methoxy-1-methylethyl)-2-propyl-1-{4-(2-trityltetrazol-5-yl)phenyl}phenylmethylimidazole-5-carboxylate

olmesartan medoxomil

methanol

1,1,1-trideuteromethanol

Refernces

• 1、 Ntountaniotis, Dimitrios,Agelis, George,Resvani, Amalia,Halabalaki, Maria,Liapakis, George,Spyridaki, Katerina,Golic Grdadolnik, Simona,Merzel, Franci,Kostidis, Sarantos,Potamitis, Constantinos,Tselios, Theodore,Matsoukas, John,Skaltsounis, Leandros Alexios,Mavromoustakos, Thomas. "An efficient synthetic method and theoretical calculations of olmesartan methyl ether: Study of biological function of AT1 antagonism". . p. 642 - 662. Retrieved 2015/04/22.
• 2、 Ntountaniotis, Dimitrios,Mavromoustakos, Thomas,Agelis, George,Resvani, Amalia,Tselios, Theodore,Matsoukas, John,Potamitis, Constantinos,Halabalaki, Maria,Skaltsounis, Leandros Alexios,Liapakis, George,Spyridaki, Katerina,Grdadolnik, Simona Golic,Merzel, Franci,Kostidis, Sarantos. "An efficient synthetic method and theoretical calculations of olmesartan methyl ether: Study of biological function of AT1 antagonism". . p. 652 - 662. Retrieved 2017/01/14.