4-ACETOXYPHENYLBORONIC ACID

Base Information

• Chemical Name: 4-ACETOXYPHENYLBORONIC ACID
• CAS No.: 177490-82-3
• Molecular Formula: C8H9BO4
• Molecular Weight: 179.968
• Hs Code.: 2931900090
• Mol file: 177490-82-3.mol

Synonyms:Boronicacid, [4-(acetyloxy)phenyl]- (9CI);4-Acetoxyphenylboronic acid;[4-(Acetyloxy)phenyl]boronic acid;

Chemical Property of 4-ACETOXYPHENYLBORONIC ACID

Chemical Property:

• Vapor Pressure: 3.46E-05mmHg at 25°C
• Melting Point: 220-224℃
• Refractive Index: 1.532
• Boiling Point: 339.9 °C at 760 mmHg
• PKA: 8.42±0.17(Predicted)
• Flash Point: 159.3 °C
• PSA: 66.76000
• Density: 1.25 g/cm³
• LogP: -0.70830
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

98% ^*data from raw suppliers

4-Acetoxyphenylboronicacid ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Irritant:
• Statements: 36/37/38
• Safety Statements: 26-37-60

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-ACETOXYPHENYLBORONIC ACID

There total 2 articles about 4-ACETOXYPHENYLBORONIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-methoxyphenylboronic acid (5720-07-0) + acetyl chloride (75-36-5) → (4-acetoxyphenyl)boronic acid (177490-82-3)

Guidance literature:

4-methoxyphenylboronic acid; acetyl chloride; In toluene; at -10 - 0 ℃; for 1h; Inert atmosphere; Large scale;

With aluminum (III) chloride; In toluene; at 0 - 80 ℃; Large scale;

Reference yield:

(p-hydroxyphenyl)boronic acid (71597-85-8) + acetic anhydride (108-24-7) → (4-acetoxyphenyl)boronic acid (177490-82-3)

Guidance literature:

With pyridine; dmap; at 20 ℃; for 8h;

Reference yield: 99.0%

C19H15BiO5S2 + (4-acetoxyphenyl)boronic acid (177490-82-3) → C20H15BiO4S

Guidance literature:

With potassium carbonate; In water; toluene; at 60 ℃; for 2h;

DOI:10.1038/s41557-020-0425-4

upstream raw materials:

(p-hydroxyphenyl)boronic acid

acetic anhydride

4-methoxyphenylboronic acid

acetyl chloride

Downstream raw materials:

4-chlorophenyl acetate

4-acetoxyphenylboroxine

4-(2-(2-methoxybenzamido)phenoxy)phenyl acetate

(E)-4-(1,3-diphenylbut-1-enyl)phenyl acetate

Refernces

• 1、 -. "Small molecule thienopyrimidine-based protein tyrosine kinase inhibitors". Page/Page column 41. . Retrieved 2010/02/15.