2-(4-IODOPHENYL)ETHYLAMINE

Base Information

• Chemical Name: 2-(4-IODOPHENYL)ETHYLAMINE
• CAS No.: 73918-57-7
• Molecular Formula: C8H10IN
• Molecular Weight: 247.079
• Hs Code.: 2921199990
• Mol file: 73918-57-7.mol

Synonyms:2-(4-Iodophenyl)ethylamine;4-Iodophenethylamine;p-Iodophenethylamine;p-Iodophenylethylamine;

Chemical Property of 2-(4-IODOPHENYL)ETHYLAMINE

Chemical Property:

• Boiling Point: 265.8 °C at 760 mmHg
• PKA: 9.72±0.10(Predicted)
• Flash Point: 114.5 °C
• PSA: 26.02000
• Density: 1.669 g/cm³
• LogP: 2.49270

Purity/Quality:

98.5% ^*data from raw suppliers

2-(4-IODOPHENYL)ETHYLAMINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(4-IODOPHENYL)ETHYLAMINE

There total 4 articles about 2-(4-IODOPHENYL)ETHYLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-iodophenylacetonitrile (51628-12-7) → p-Iodophenylethylamine (73918-57-7)

Guidance literature:

With lithium aluminium tetrahydride; diethyl ether;

DOI:10.1021/jo01106a047

Reference yield:

2-[2-(4-iodophenyl)ethyl]-1H-isoindole-1,3(2H)-dione (874202-06-9) → p-Iodophenylethylamine (73918-57-7)

Guidance literature:

With hydrazine hydrate; In butan-1-ol; at 110 ℃; for 2h;

DOI:10.1002/anie.201102472

Reference yield:

4-iodophenethyl alcohol (52914-23-5) → p-Iodophenylethylamine (73918-57-7)

Guidance literature:

Multi-step reaction with 2 steps

1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 20 °C

2: hydrazine hydrate / butan-1-ol / 2 h / 110 °C

With hydrazine hydrate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; toluene; butan-1-ol;

DOI:10.1002/anie.201102472

upstream raw materials:

4-iodophenylacetonitrile

2-[2-(4-iodophenyl)ethyl]-1H-isoindole-1,3(2H)-dione

4-iodophenethyl alcohol

(4-iodophenyl)acetic acid

Downstream raw materials:

2-(4-iodophenyl)-N,N-bis(2-phenylethyl)ethylamine

C₃₂H₃₉IN₂O₃Si

2-[2-(4-iodophenyl)ethyl]-1H-isoindole-1,3(2H)-dione

C₅₆H₉₅NO₄Si

Refernces

• 1、 Wyffels, Leonie,Muccioli, Giulio G.,De Bruyne, Sylvie,Moerman, Lieselotte,Sambre, Johan,Lambert, Didier M.,De Vos, Filip. "Synthesis, in vitro and in vivo evaluation, and radiolabeling of aryl anandamide analogues as candidate radioligands for in vivo imaging of fatty acid amide hydrolase in the brain". supporting information; experimental part. p. 4613 - 4622. Retrieved 2010/02/28.