Technology Process of (±)-3-phenyl-2-[4-(trifluoromethyl)phenyl]propanoic acid
There total 6 articles about (±)-3-phenyl-2-[4-(trifluoromethyl)phenyl]propanoic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
manganese; (1,2-dimethoxyethane)dichloronickel(II); 4,4’-di-tert-butyl-6-methyl-2,2’-bipyridine; water;
In
1-methyl-pyrrolidin-2-one;
for 60h;
under 760.051 Torr;
Schlenk technique;
Heating;
DOI:10.1021/jacs.7b07637
- Guidance literature:
-
With
1,4-diaza-bicyclo[2.2.2]octane; (4,4'-di-tert-butyl-2,2'-dipyridyl)-bis-(2-phenylpyridine(-1H))-iridium(III) hexafluorophosphate; potassium formate; potassium carbonate;
In
dimethyl sulfoxide;
at 25 - 30 ℃;
for 24h;
under 760.051 Torr;
regioselective reaction;
Schlenk technique;
Irradiation;
DOI:10.1021/jacs.0c03144
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / tetrahydrofuran / 0.17 h / 70 °C
1.2: 16 h
2.1: zinc; [2-((diphenylphospino)methyl)-2-methyl-1,3-propanediyl]bis[diphenylphosphine]; formic acid; (1,2-dimethoxyethane)dichloronickel(II) / 1,4-dioxane / 16 h / 120 °C / Inert atmosphere; Schlenk technique; Sealed tube
3.1: 4,4’-di-tert-butyl-6-methyl-2,2’-bipyridine; manganese; water; (1,2-dimethoxyethane)dichloronickel(II) / 1-methyl-pyrrolidin-2-one / 60 h / 760.05 Torr / Schlenk technique; Heating
With
bis-triphenylphosphine-palladium(II) chloride; manganese; copper(l) iodide; formic acid; (1,2-dimethoxyethane)dichloronickel(II); 4,4’-di-tert-butyl-6-methyl-2,2’-bipyridine; water; triethylamine; zinc; [2-((diphenylphospino)methyl)-2-methyl-1,3-propanediyl]bis[diphenylphosphine];
In
tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one;
DOI:10.1021/jacs.7b07637