3-(2-Methoxyphenyl)aniline

Base Information

• Chemical Name: 3-(2-Methoxyphenyl)aniline
• CAS No.: 96923-01-2
• Molecular Formula: C13H14ClNO
• Molecular Weight: 199.252
• Hs Code.: 2922299090
• European Community (EC) Number: 673-292-6
• Mol file: 96923-01-2.mol

Synonyms:3-(2-methoxyphenyl)aniline;96923-01-2;2'-methoxy-biphenyl-3-ylamine;(2'-methoxybiphenyl-3-yl)amine;2'-Methoxy-[1,1'-biphenyl]-3-amine;[1,1'-Biphenyl]-3-amine, 2'-methoxy-;MFCD03424666;2'-methoxy[1,1'-biphenyl]-3-amine;2'-methoxybiphenyl-3-ylamine;SCHEMBL1039794;AKOS002683312;AS-31038;BP-21736;SY003507;BB 0222459;FT-0677833;EN300-56326;A24524;Z732776322

Chemical Property of 3-(2-Methoxyphenyl)aniline

Chemical Property:

• Boiling Point: 340.3 °C at 760 mmHg
• Flash Point: 166.3 °C
• PSA: 35.25000
• Density: 1.1g/cm3
• LogP: 4.32760
• Storage Temp.: 2-8°C
• XLogP3: 3.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 199.099714038
• Heavy Atom Count: 15
• Complexity: 195

Purity/Quality:

98%min ^*data from raw suppliers

3-(2-Methoxyphenyl)aniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=CC=C1C2=CC(=CC=C2)N
• Uses: 2''-Methoxy-[1,1''-biphenyl]-3-amine, HCl

Technology Process of 3-(2-Methoxyphenyl)aniline

There total 11 articles about 3-(2-Methoxyphenyl)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-Methoxyphenylboronic acid (5720-06-9) + m-Bromoaniline (591-19-5) → 3-amino-2'-methoxybiphenyl (96923-01-2)

Guidance literature:

With potassium carbonate; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In methanol; water; toluene; at 135 ℃; for 0.583333h; Irradiation;

Reference yield: 88.0%

2-methoxy-3'-nitrobiphenyl (96922-97-3) → 3-amino-2'-methoxybiphenyl (96923-01-2)

Guidance literature:

With hydrogen; palladium on activated charcoal; for 3h; under 2585.7 Torr;

DOI:10.1016/0040-4020(84)85070-X

Reference yield: 86.0%

m-nitrobromobenzene (585-79-5) + 2-Methoxyphenylboronic acid (5720-06-9) → 3-amino-2'-methoxybiphenyl (96923-01-2)

Guidance literature:

With β-D-mannose; palladium diacetate; potassium carbonate; In water; N,N-dimethyl-formamide; at 130 ℃; for 1h; Microwave irradiation; Green chemistry;

DOI:10.1039/c5ra04129e

upstream raw materials:

2-methoxy-3'-nitrobiphenyl

2-bromoanisole

3-Aminophenylboronic acid

3-nitrophenyldiazonium tetrafluoroborate

Downstream raw materials:

3-(2-methoxyphenyl)-4'-N,N-dimethylaminobenzene

2-methoxy-1,1'-biphenyl

Refernces

• 1、 -. "1-CYANO-PYRROLIDINE DERIVATIVES AS INHIBITORS OF USP30.". Page/Page column 53. . Retrieved 2018/02/03.
• 2、 Tang, Jing,Liu, Feng,Nagy, Eva,Miller, Lena,Kirby, Karen A.,Wilson, Daniel J.,Wu, Bulan,Sarafianos, Stefan G.,Parniak, Michael A.,Wang, Zhengqiang. "3-Hydroxypyrimidine-2,4-diones as Selective Active Site Inhibitors of HIV Reverse Transcriptase-Associated RNase H: Design, Synthesis, and Biochemical Evaluations". . p. 2648 - 2659. Retrieved 2016/04/10.