1-(2'-Methyl[1,1'-biphenyl]-4-yl)ethanone

Base Information

• Chemical Name: 1-(2'-Methyl[1,1'-biphenyl]-4-yl)ethanone
• CAS No.: 56917-39-6
• Molecular Formula: C15H14O
• Molecular Weight: 210.276
• DSSTox Substance ID: DTXSID00393262
• Nikkaji Number: J1.331.474H
• Mol file: 56917-39-6.mol

Synonyms:56917-39-6;1-(2'-methyl[1,1'-biphenyl]-4-yl)ethanone;1-(2'-Methyl-biphenyl-4-yl)-ethanone;1-[4-(2-methylphenyl)phenyl]ethanone;2-Methyl-4'-acetylbiphenyl;SCHEMBL2772796;DTXSID00393262;MFCD04039117;AKOS004113779;BB 0222555;FT-0764248

Chemical Property of 1-(2'-Methyl[1,1'-biphenyl]-4-yl)ethanone

Chemical Property:

• Boiling Point: 324 °C at 760 mmHg
• Flash Point: 137.5 °C
• PSA: 17.07000
• Density: 1.038g/cm³
• LogP: 3.86460
• XLogP3: 3.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 210.104465066
• Heavy Atom Count: 16
• Complexity: 238

Purity/Quality:

98%Min ^*data from raw suppliers

1-(2'-Methyl-biphenyl-4-yl)-ethanone 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=CC=C1C2=CC=C(C=C2)C(=O)C

Technology Process of 1-(2'-Methyl[1,1'-biphenyl]-4-yl)ethanone

There total 33 articles about 1-(2'-Methyl[1,1'-biphenyl]-4-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-Methylphenylboronic acid (16419-60-6) + para-bromoacetophenone (99-90-1) → 4-acetyl-2'-methylbiphenyl (56917-39-6)

Guidance literature:

With potassium phosphate; water; In toluene; at 100 ℃; for 1h;

DOI:10.1016/j.jorganchem.2008.07.003

Reference yield: 100.0%

2-Methylphenylboronic acid (16419-60-6) + para-chloroacetophenone (99-91-2) → 4-acetyl-2'-methylbiphenyl (56917-39-6)

Guidance literature:

With potassium fluoride; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; tri-tert-butyl phosphine; In tetrahydrofuran; at 20 ℃; for 6h;

DOI:10.1021/ja0002058

Reference yield: 99.0%

ortho-methylphenyl iodide (615-37-2) + 4-acetylphenylboronic acid (149104-90-5) → 4-acetyl-2'-methylbiphenyl (56917-39-6)

Guidance literature:

With silver tetrafluoroborate; C₁₆H₃₆N⁽¹⁺⁾*C₃₂H₂₅Cl₂Fe₂N₂O₃PdS^(1-); potassium carbonate; In water; for 0.25h; Microwave irradiation;

DOI:10.1016/j.tetlet.2012.02.102

upstream raw materials:

4-acetylphenyl mesylate

2-Methylphenylboronic acid

ortho-methylphenyl iodide

4-acetylphenylboronic acid

Refernces

• 1、 Dong, Ying,Li, Wen-Han,Dong, Yu-Bin. "Dual-Metal N-Heterocyclic Carbene Complex (M = Au and Pd)-Functionalized UiO-67 MOF for Alkyne Hydration-Suzuki Coupling Tandem Reaction". . p. 1818 - 1826. Retrieved 2021/01/13.
• 2、 Zhang, Hao,Zhu, Ji-Hua,Hou, Fei,Quan, Zheng-Jun,Wang, Xi-Cun. "A catalytic system with high efficiency and recyclability based on Suzuki and Heck reaction in aqueous admicellar medium". . . Retrieved 2020/01/24.