4-(PYRROLIDIN-1-YLMETHYL)BENZALDEHYDE 97

Base Information

• Chemical Name: 4-(PYRROLIDIN-1-YLMETHYL)BENZALDEHYDE 97
• CAS No.: 650628-72-1
• Molecular Formula: C12H15 N O
• Molecular Weight: 189.257
• Hs Code.: 2933990090
• Mol file: 650628-72-1.mol

Synonyms:4-(Pyrrolidin-1-ylmethyl)benzaldehyde; 4-(Pyrrolidinomethyl)benzaldehyde

Chemical Property of 4-(PYRROLIDIN-1-YLMETHYL)BENZALDEHYDE 97

Chemical Property:

• Vapor Pressure: 0.00123mmHg at 25°C
• Boiling Point: 298.9oC at 760 mmHg
• Flash Point: 109.6oC
• PSA: 20.31000
• Density: 1.114g/cm3
• LogP: 2.03280

Purity/Quality:

98%min ^*data from raw suppliers

4-[(Pyrrolidin-1-yl)methyl]benzaldehyde 97% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: C

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(PYRROLIDIN-1-YLMETHYL)BENZALDEHYDE 97

There total 11 articles about 4-(PYRROLIDIN-1-YLMETHYL)BENZALDEHYDE 97 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

→ 4-[(pyrrolidin-1-yl)methyl]-benzaldehyde (650628-72-1)

Guidance literature:

Reference yield: 85.0%

4-(tetrahydro-1H-1-pyrrolylmethyl)phenylmethanol (91271-60-2) → 4-[(pyrrolidin-1-yl)methyl]-benzaldehyde (650628-72-1)

Guidance literature:

With manganese(IV) oxide; In 1,4-dioxane; at 80 ℃; for 1h;

Reference yield: 54.1%

4-Pyrrolidin-1-ylmethyl-benzoic acid methyl ester (160598-45-8) → 4-[(pyrrolidin-1-yl)methyl]-benzaldehyde (650628-72-1)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; pentane; at 20 ℃; for 2h;

DOI:10.1016/j.ejmech.2008.03.003

upstream raw materials:

4-(tetrahydro-1H-1-pyrrolylmethyl)phenylmethanol

Methyl 4-(bromomethyl)benzoate

4-Pyrrolidin-1-ylmethyl-benzoic acid methyl ester

pyrrolidine

Downstream raw materials:

(E)-5,6-dimethoxy-2-{4-[(pyrrolidin-1-yl)methyl]-benzylidene}-2,3-dihydroinden-1-one

[(6-amino-2-butoxy-5-nitro-pyrimidin-4-yl)-(4-pyrrolidin-1-ylmethyl-benzyl)amino]acetic acid ethyl ester

4-amino-2-n-butoxy-8-[4’-(pyrrolidin-1“-ylmethyl)-benzyl]-5,6,7,8-tetrahydropteridin-6-one

Refernces

• 1、 Whitehouse, Andrew J.,Thomas, Sherine E.,Brown, Karen P.,Fanourakis, Alexander,Chan, Daniel S.-H.,Libardo, M. Daben J.,Mendes, Vitor,Boshoff, Helena I. M.,Floto, R. Andres,Abell, Chris,Blundell, Tom L.,Coyne, Anthony G.. "Development of inhibitors against mycobacterium abscessus tRNA (m1G37) Methyltransferase (TrmD) Using Fragment-Based Approaches". . p. 7210 - 7232. Retrieved 2019/08/20.
• 2、 -. "METHODS OF PREPARING TOLL-LIKE RECEPTOR MODULATORS". Paragraph 0236. . Retrieved 2016/04/09.