2-(Benzofuran-3-yl)ethanamine

Base Information

• Chemical Name: 2-(Benzofuran-3-yl)ethanamine
• CAS No.: 27404-31-5
• Molecular Formula: C10H11NO
• Molecular Weight: 161.203
• Hs Code.: 2932999099
• European Community (EC) Number: 696-142-1
• ChEMBL ID: CHEMBL205957
• DSSTox Substance ID: DTXSID20497453
• Nikkaji Number: J3.438.689G
• Wikidata: Q82347017
• Mol file: 27404-31-5.mol

Synonyms:2-(benzofuran-3-yl)ethanamine;27404-31-5;2-(1-benzofuran-3-yl)ethanamine;2-BENZO[B]FURAN-3-YLETHYLAMINE;2-(1-benzofuran-3-yl)ethan-1-amine;MFCD08271905;C10H11NO;3-(2-Aminoethyl)benzofuran;2-(1-Benzofuran-3-yl)ethylamine;2-(1-benzofuran-3-yl)-ethylamine;SCHEMBL140189;CHEMBL205957;2-(3benzo[b]furanyl)ethylamine;2-(3-benzo[b]furanyl)ethylamine;DTXSID20497453;NEHYFMQXSNIAMZ-UHFFFAOYSA-N;2-(3-benzo[b]furanyl)-ethylamine;BCP32324;AKOS006343729;AM85692;CS-W019375;DS-1488;FS-3392;SB36334;FT-0758359;EN300-171188;J-506225;2-(1-Benzofuran-3-yl)ethanamine;2-Benzo[b]furan-3-ylethylamine

Chemical Property of 2-(Benzofuran-3-yl)ethanamine

Chemical Property:

• Vapor Pressure: 0.008mmHg at 25°C
• Melting Point: 183-185 °C
• Refractive Index: 1.609
• Boiling Point: 268.529 °C at 760 mmHg
• PKA: 9.71±0.10(Predicted)
• Flash Point: 116.202 °C
• PSA: 39.16000
• Density: 1.129 g/cm³
• LogP: 2.63430
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 161.084063974
• Heavy Atom Count: 12
• Complexity: 149

Purity/Quality:

99%, ^*data from raw suppliers

2-(Benzofuran-3-yl)ethanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C(=CO2)CCN

Technology Process of 2-(Benzofuran-3-yl)ethanamine

There total 15 articles about 2-(Benzofuran-3-yl)ethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

→ 2-(benzofuran-3-yl)ethanamine (27404-31-5)

Guidance literature:

Reference yield: 71.0%

3-cyanomethylbenzo[b]furan (52407-43-9) → 2-(benzofuran-3-yl)ethanamine (27404-31-5)

Guidance literature:

aluminum nickel; In methanol;

Reference yield:

3-oxo-2,3-dihydrobenzo[b]furan (7169-34-8) → 2-(benzofuran-3-yl)ethanamine (27404-31-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 82 percent / NaH / tetrahydrofuran / 2 h / 20 °C

2.1: NH₃; H₂ / Raney Nickel / ethanol / 3 h / 60 °C / 45003.6 Torr

2.2: 68 percent / hydrochloric acid gas / diethyl ether

3.1: K₂CO₃ / H₂O / 2 h / pH 9

With ammonia; hydrogen; sodium hydride; potassium carbonate; nickel; In tetrahydrofuran; ethanol; water;

upstream raw materials:

3-cyanomethylbenzo[b]furan

N-2-(benzo[b]furan-3-yl)ethylamine hydrochloride

3-oxo-2,3-dihydrobenzo[b]furan

1-benzofuran-3-carbaldehyde

Downstream raw materials:

3-(2-Formamidoethyl)benzo[b]furan

5-bromo-furan-2-carboxylic acid (2-benzofuran-3-yl-ethyl)-(3-methyl-but-2-enyl)-amide

6,7-dihydro-5H-10-oxa-7-azabenzo[a]azulene-9-carboxylic acid ethyl ester

3,4-dihydro-1H-benzo[4,5]furo[2,3-c]pyridine

Refernces

• 1、 -. "Azepinoindole derivatives as pharmaceutical agents". . . Retrieved 2008/06/13.
• 2、 -. "AZEPINOINDOLE AND PYRIDOINDOLE DERIVATIVES AS PHARMACEUTICAL AGENTS". Page 135. . Retrieved 2008/06/13.