3-(1,3-dioxolan-2-yl)thiophene-2-sulfonyl Chloride

Base Information

• Chemical Name: 3-(1,3-dioxolan-2-yl)thiophene-2-sulfonyl Chloride
• CAS No.: 103011-38-7
• Molecular Formula: C7H7 Cl O4 S2
• Molecular Weight: 254.715
• Hs Code.: 2934999090
• European Community (EC) Number: 874-759-9
• DSSTox Substance ID: DTXSID00441494
• Wikidata: Q82258275
• Mol file: 103011-38-7.mol

Synonyms:3-(1,3-dioxolan-2-yl)thiophene-2-sulfonyl Chloride;103011-38-7;3-(1,3-Dioxolan-2-yl)thiophene-2-sulphonyl chloride;SCHEMBL3017019;DTXSID00441494;RRTOURREASJQSR-UHFFFAOYSA-N;MFCD08271969;AKOS015908630;PS-10864;CS-0216313;FT-0702668;EN300-395415;3-(1,3-dioxolan-2-yl)thiophene-2-sulfonylChloride;3-(1,3-dioxolan-2-yl)-thiophene-2-sulfonyl chloride;3-(1,3-dioxolan-2-yl)thiophene-2-sulfonyl chloride, AldrichCPR

Chemical Property of 3-(1,3-dioxolan-2-yl)thiophene-2-sulfonyl Chloride

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 93 °C
• Boiling Point: 365.3°Cat760mmHg
• Flash Point: 174.7°C
• PSA: 89.22000
• Density: 1.58g/cm³
• LogP: 2.80180
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 2
• Exact Mass: 253.9474287
• Heavy Atom Count: 14
• Complexity: 293

Purity/Quality:

98%min ^*data from raw suppliers

3-(1,3-Dioxolan-2-yl)thiophene-2-sulfonylChloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COC(O1)C2=C(SC=C2)S(=O)(=O)Cl

Technology Process of 3-(1,3-dioxolan-2-yl)thiophene-2-sulfonyl Chloride

There total 1 articles about 3-(1,3-dioxolan-2-yl)thiophene-2-sulfonyl Chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(thiophen-3-yl)-1,3-dioxolane (13250-82-3) → 3-(1,3-dioxolan-2-yl)thiophene-2-sulfonyl chloride (103011-38-7)

Guidance literature:

With N-chloro-succinimide; n-butyllithium; sulfur dioxide; Yield given; Multistep reaction;

DOI:10.1002/jhet.5570360111

Reference yield: 75.0%

2-(thiophen-3-yl)-1,3-dioxolane (13250-82-3) + 4-methoxy-aniline (104-94-9) + 3-(1,3-dioxolan-2-yl)thiophene-2-sulfonyl chloride (103011-38-7) → 3-(1,3-Dioxolan-2-yl)-N-(4-methoxyphenyl)-thiophene-2-sulfonamide

Guidance literature:

With triethylamine; In tetrahydrofuran;

Reference yield: 72.0%

cyclohexylamine (108-91-8,157973-60-9) + 3-(1,3-dioxolan-2-yl)thiophene-2-sulfonyl chloride (103011-38-7) → 3-(1,3-dioxolan-2-yl)-N-cyclohexyl-2-thiophenesulfonamide (286958-41-6)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃;

DOI:10.1016/S0968-0896(00)00026-2

upstream raw materials:

2-(thiophen-3-yl)-1,3-dioxolane

Downstream raw materials:

3-(1,3-dioxolan-2-yl)-N-(3-methoxyphenyl)-2-thiophenesulfonamide

3-(1,3-dioxolan-2-yl)-N-[4-(4-morpholinyl)phenyl]-2-thiophenesulfonamide

3-(1,3-dioxolan-2-yl)-N-cyclohexyl-2-thiophenesulfonamide

3-(1,3-dioxolan-2-yl)-N-(3,4-dimethoxyphenyl)-2-thiophenesulfonamide

Refernces

• 1、 Dantanarayana, Anura P.,DuPre, Brian,May, Jesse A.,Lynch, Vincent M.. "A convenient synthesis of the novel 5H-thieno[2,3-e]-4,1,2- oxathiazepine ring system via an alkoxycarbenium ion intermediate". . p. 65 - 73. Retrieved 2007/10/03.