2-(Benzofuran-3-yl)ethanol

Base Information

• Chemical Name: 2-(Benzofuran-3-yl)ethanol
• CAS No.: 75611-06-2
• Molecular Formula: C10H10O2
• Molecular Weight: 162.188
• Hs Code.: 2932999099
• DSSTox Substance ID: DTXSID30449544
• Nikkaji Number: J907.871A
• Wikidata: Q82269055
• Mol file: 75611-06-2.mol

Synonyms:2-(benzofuran-3-yl)ethanol;75611-06-2;2-Benzo[b]furan-3-ylethanol;2-(1-benzofuran-3-yl)ethanol;3-(2-Hydroxyethyl)benzofuran;2-(1-benzofuran-3-yl)ethan-1-ol;MFCD08271904;SCHEMBL735027;2-(benzo[b]furan-3-yl)ethanol;DTXSID30449544;2-(Benzofuran-3-yl)ethan-1-ol;QBEGKDXITSPUTE-UHFFFAOYSA-N;AC6763;AKOS006343728;MS-22285;SY045627;CS-0455531;FT-0737777;EN300-1243094;A865652;J-506226

Chemical Property of 2-(Benzofuran-3-yl)ethanol

Chemical Property:

• Vapor Pressure: 0.002mmHg at 25°C
• Refractive Index: 1.612
• Boiling Point: 279.793 °C at 760 mmHg
• PKA: 14.78±0.10(Predicted)
• Flash Point: 123.015 °C
• PSA: 33.37000
• Density: 1.187 g/cm³
• LogP: 1.96760
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 1.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 162.068079557
• Heavy Atom Count: 12
• Complexity: 147

Purity/Quality:

98%min ^*data from raw suppliers

2-(Benzofuran-3-yl)ethanol 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C(=CO2)CCO

Technology Process of 2-(Benzofuran-3-yl)ethanol

There total 13 articles about 2-(Benzofuran-3-yl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

benzofuran-3-yl-acetic acid ethyl ester (82156-58-9) → 2-(benzofuran-3-yl)ethan-1-ol (75611-06-2)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at -78 ℃;

DOI:10.1016/S0040-4039(99)00840-0

Reference yield: 98.0%

lithium aluminium tetrahydride (16853-85-3) + benzofuran-3-yl-acetic acid ethyl ester (82156-58-9) → 2-(benzofuran-3-yl)ethan-1-ol (75611-06-2)

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 1h;

Reference yield: 91.0%

methyl 2-(benzofuran-3-yl)acetate (26278-23-9) → 2-(benzofuran-3-yl)ethan-1-ol (75611-06-2)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; at 20 ℃; for 1h;

upstream raw materials:

benzofuran-3-yl-acetic acid ethyl ester

2-Iodophenol

1-tert-butyldimethylsilyl-4-(tert-butyldimethylsilyloxy)but-1-yne

(E)-4-(2-Iodo-phenoxy)-but-2-enoic acid ethyl ester

Downstream raw materials:

2-(benzofuran-3-yl)ethyl 4-methylbenzenesulfonate

(2R,3R,4R,5R,6R)-6-(5-Azido-pentyloxymethyl)-2-(2-benzofuran-3-yl-ethoxy)-4,5-bis-benzyloxy-tetrahydro-pyran-3-ol

N-[(4aR,6R,7R,8R,8aS)-6-(2-Benzofuran-3-yl-ethoxy)-8-hydroxy-2,2-dimethyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl]-2-fluoro-5-nitro-benzamide

2-(2-hydroxyphenyl)anthraquinone

Refernces

• 1、 Retich, Christina,Br?se, Stefan. "Asymmetric Organocatalytic Synthesis of Bisindoles – Scope and Derivatizations". supporting information. p. 60 - 77. Retrieved 2018/01/17.
• 2、 Xie, Qiqiang,Ni, Chuanfa,Zhang, Rongyi,Li, Lingchun,Rong, Jian,Hu, Jinbo. "Efficient Difluoromethylation of Alcohols Using TMSCF2Br as a Unique and Practical Difluorocarbene Reagent under Mild Conditions". supporting information. p. 3206 - 3210. Retrieved 2017/03/17.