4-THIEN-3-YLBENZOYL CHLORIDE

Base Information

• Chemical Name: 4-THIEN-3-YLBENZOYL CHLORIDE
• CAS No.: 181132-79-6
• Molecular Formula: C11H7 Cl O S
• Molecular Weight: 222.69
• Mol file: 181132-79-6.mol

Synonyms:4-THIEN-3-YLBENZOYL CHLORIDE;4-Thien-3-ylbenzoyl chloride 97%

Chemical Property of 4-THIEN-3-YLBENZOYL CHLORIDE

Chemical Property:

• Vapor Pressure: 0.000626mmHg at 25°C
• Melting Point: 144.5-146.5
• Boiling Point: 309.8°Cat760mmHg
• Flash Point: 141.1°C
• PSA: 45.31000
• Density: 1.305g/cm³
• LogP: 3.79410

Purity/Quality:

98%min ^*data from raw suppliers

4-THIEN-3-YLBENZOYL CHLORIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-THIEN-3-YLBENZOYL CHLORIDE

There total 3 articles about 4-THIEN-3-YLBENZOYL CHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(thiophen-3-yl)benzoic acid (29886-64-4) → 4-(thiophen-3-yl)benzoic acid chloride (181132-79-6)

Guidance literature:

With thionyl chloride; at 20 ℃; for 2h;

DOI:10.1002/ardp.200700261

Reference yield:

4-methoxycarbonylphenyl bromide (619-42-1) → 4-(thiophen-3-yl)benzoic acid chloride (181132-79-6)

Guidance literature:

Multi-step reaction with 3 steps

1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / tetrahydrofuran; water / 12 h / 70 °C / Inert atmosphere

2: water; potassium hydroxide / tetrahydrofuran; ethanol / Reflux

3: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; oxalyl dichloride; water; sodium carbonate; N,N-dimethyl-formamide; potassium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; water;

DOI:10.1002/chem.201705710

Reference yield:

4-(thien-3-yl)benzoic acid methyl ester (20608-91-7) → 4-(thiophen-3-yl)benzoic acid chloride (181132-79-6)

Guidance literature:

Multi-step reaction with 2 steps

1: water; potassium hydroxide / tetrahydrofuran; ethanol / Reflux

2: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere

With oxalyl dichloride; water; N,N-dimethyl-formamide; potassium hydroxide; In tetrahydrofuran; ethanol; dichloromethane;

DOI:10.1002/chem.201705710

upstream raw materials:

4-(thiophen-3-yl)benzoic acid

4-methoxycarbonylphenyl bromide

4-(thien-3-yl)benzoic acid methyl ester

Downstream raw materials:

N-phenyl-4-(thiophen-3-yl)benzamide

N-benzyl-4-(thiophen-3-yl)benzamide

benzyl 4-(thiophen-3-yl)benzoate

phenyl 4-(thiophen-3-yl)benzoate

Refernces

• 1、 Holzer, Marcel,Ziegler, Sigrid,Neugebauer, Alexander,Kronenberger, Bernd,Klein, Christian D.,Hartmann, Rolf W.. "Structural modifications of salicylates: Inhibitors of human CD81-receptor HCV-E2 interaction". experimental part. p. 478 - 484. Retrieved 2009/04/04.