Technology Process of tert-butyl 3-(2,6-dimethyl-4-carbamoylphenyl)propanoate
There total 10 articles about tert-butyl 3-(2,6-dimethyl-4-carbamoylphenyl)propanoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen;
palladium on activated charcoal;
In
ethyl acetate;
at 60 ℃;
for 2h;
under 3102.89 Torr;
DOI:10.1021/jm060369k
- Guidance literature:
-
4-(2-tert-butoxycarbonyl-ethyl)-3,5-dimethyl-benzoic acid;
With
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
isopropyl alcohol;
at 20 ℃;
for 1h;
With
ammonia;
In
water; isopropyl alcohol;
for 0.5h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 94 percent / PdCl2(Ph3)2; CuI; KI / Et3N / dimethylformamide / 0.83 h / 110 °C / microwave irradiation
2: 76 percent / NH3 / methanol / 72 h / 20 °C
3: 98 percent / H2 / Pd/C / ethyl acetate / 2 h / 60 °C / 3102.89 Torr
With
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; ammonia; hydrogen; potassium iodide;
palladium on activated charcoal; triethylamine;
In
methanol; ethyl acetate; N,N-dimethyl-formamide;
1: Heck coupling;
DOI:10.1021/jm060369k
