5'-O-(4,4'-dimethoxytrityl)-5-azacytidine

Base Information

• Chemical Name: 5'-O-(4,4'-dimethoxytrityl)-5-azacytidine
• CAS No.: 107036-45-3
• Molecular Formula: C₂₉H₃₀N₄O₇
• Molecular Weight: 546.58
• Mol file: 107036-45-3.mol

Synonyms:5'-O-(4,4'-dimethoxytrityl)-5-azacytidine

Chemical Property of 5'-O-(4,4'-dimethoxytrityl)-5-azacytidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5'-O-(4,4'-dimethoxytrityl)-5-azacytidine

There total 1 articles about 5'-O-(4,4'-dimethoxytrityl)-5-azacytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

4,4'-dimethoxytrityl chloride (40615-36-9) + 5-azacytidine (320-67-2) → 5'-O-(4,4'-dimethoxytrityl)-5-azacytidine (107036-45-3)

Guidance literature:

With pyridine;

DOI:10.1021/jm00388a020

Reference yield: 90.0%

1,1'-Thiocarbonyldiimidazole (6160-65-2) + 5'-O-(4,4'-dimethoxytrityl)-5-azacytidine (107036-45-3) → 5'-O-(4,4'-dimethoxytrityl)-5-azacytidine 2',3'-O-(cyclic thiocarbonate) (107036-46-4)

Guidance literature:

In acetonitrile;

DOI:10.1021/jm00388a020

Reference yield:

5'-O-(4,4'-dimethoxytrityl)-5-azacytidine (107036-45-3) → 2',3'-dideoxy-5'-O-(4,4'-dimethoxytrityl)-5-azacytidine (107036-51-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / acetonitrile

2: 2.) α,α'-azoisobutyronitrile (AIBN), (n-Bu)3SnH, 4.) AIBN, (N-Bu3)SnH

With 2,2'-azobis(isobutyronitrile); azobisisobutyronitrile; tri-n-butyl-tin hydride; In acetonitrile;

DOI:10.1021/jm00388a020

upstream raw materials:

4,4'-dimethoxytrityl chloride

5-azacytidine

Downstream raw materials:

5'-O-(4,4'-dimethoxytrityl)-5-azacytidine 2',3'-O-(cyclic thiocarbonate)

2',3'-dideoxy-5'-O-(4,4'-dimethoxytrityl)-5-azacytidine

5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-5-azacytidine

5'-O-(4,4'-dimethoxytrityl)-3'-deoxy-5-azacytidine

Refernces

• 1、 Kim, Chong-Ho,Marquez, Victor E.,Broder, Samuel,Mitsuya, Hiroaki,Driscoll, John S.. "Potent Anti-AIDS Drugs. 2',3'-Dideoxycytidine Analogues". . p. 862 - 866. Retrieved 2007/10/02.