2-bromo-1-iodo-3,4,5-trimethoxybenzene

Base Information

• Chemical Name: 2-bromo-1-iodo-3,4,5-trimethoxybenzene
• CAS No.: 1246764-26-0
• Molecular Formula: C₉H₁₀BrIO₃
• Molecular Weight: 372.985
• Mol file: 1246764-26-0.mol

Synonyms:2-bromo-1-iodo-3,4,5-trimethoxybenzene

Chemical Property of 2-bromo-1-iodo-3,4,5-trimethoxybenzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-bromo-1-iodo-3,4,5-trimethoxybenzene

There total 1 articles about 2-bromo-1-iodo-3,4,5-trimethoxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

5-iodo-1,2,3-trimethoxybenzene (25245-29-8) → 2-bromo-1-iodo-3,4,5-trimethoxybenzene (1246764-26-0)

Guidance literature:

With bromine; In acetic acid;

DOI:10.1016/j.ejmech.2010.05.007

Reference yield: 85.0%

6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzo[d][1,3]dioxole-5-carbaldehyde + 2-bromo-1-iodo-3,4,5-trimethoxybenzene (1246764-26-0) → 6-(2-bromo-3,4,5-trimethoxyphenyl)benzo[d][1,3]dioxole-5-carbaldehyde

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; tripotassium phosphate "n" hydrate; In toluene; at 100 ℃; for 12h; Schlenk technique; Inert atmosphere;

DOI:10.1021/acs.orglett.6b00269

Reference yield:

2-bromo-1-iodo-3,4,5-trimethoxybenzene (1246764-26-0) + trimethylsilylacetylene (1066-54-2) → C14H19BrO3Si

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In tetrahydrofuran; at 20 ℃;

DOI:10.1016/j.ejmech.2010.05.007

upstream raw materials:

5-iodo-1,2,3-trimethoxybenzene

Refernces

• 1、 Rasolofonjatovo, Evelia,Provot, Olivier,Hamze, Abdallah,Bignon, Jérome,Thoret, Sylviane,Brion, Jean-Daniel,Alami, Mouad. "Regioselective hydrostannation of diarylalkynes directed by a labile ortho bromine atom: An easy access to stereodefined triarylolefins, hybrids of combretastatin A-4 and isocombretastatin A-4". experimental part. p. 3617 - 3626. Retrieved 2010/09/05.