2,4-Dimethyl-3-hydroxypyridine

Base Information

• Chemical Name: 2,4-Dimethyl-3-hydroxypyridine
• CAS No.: 27296-76-0
• Molecular Formula: C7H9NO
• Molecular Weight: 123.155
• Hs Code.: 2933399090
• UNII: G70YFU2M1J
• ChEMBL ID: CHEMBL134480
• DSSTox Substance ID: DTXSID90567511
• Nikkaji Number: J2.136.109G
• Wikidata: Q82453413
• Mol file: 27296-76-0.mol

Synonyms:2,4-Dimethyl-3-hydroxypyridine;27296-76-0;2,4-dimethylpyridin-3-ol;3-Pyridinol, 2,4-dimethyl-;G70YFU2M1J;2,4-DIMETHYL-3-PYRIDINOL;3-Pyridinol,2,4-dimethyl-;UNII-G70YFU2M1J;CHEMBL134480;SCHEMBL1128280;3-hydroxy-2,4-dimethylpyridine;4,6-Dimethyl-5-hydroxypyridine;5-Hydroxy-4,6-dimethylpyridine;DTXSID90567511;YOLWXYGTOQALFW-UHFFFAOYSA-N;MFCD08235268;AKOS016009389;AB43831;PS-6147;CS-0205444;F17537;W-202149

Chemical Property of 2,4-Dimethyl-3-hydroxypyridine

Chemical Property:

• Vapor Pressure: 0.001mmHg at 25°C
• Melting Point: 37-40 °C
• Refractive Index: 1.544
• Boiling Point: 295.409 °C at 760 mmHg
• Flash Point: 132.459 °C
• PSA: 33.12000
• Density: 1.084 g/cm³
• LogP: 1.40400
• Storage Temp.: 2-8°C
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 123.068413911
• Heavy Atom Count: 9
• Complexity: 94.9

Purity/Quality:

98% ^*data from raw suppliers

2,4-Dimethyl-3-hydroxypyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(C(=NC=C1)C)O

Technology Process of 2,4-Dimethyl-3-hydroxypyridine

There total 10 articles about 2,4-Dimethyl-3-hydroxypyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

2,4-dimethyl-1-tosyl-1,2-dihydropyridin-3(6H)-one (1173164-95-8) → 2,4-dimethyl-pyridin-3-ol (27296-76-0)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; at 20 ℃;

DOI:10.1016/j.tet.2009.07.076

Reference yield: 68.0%

1-benzyl-2,4-dimethyl-1,6-dihydro-2H-pyridin-3-one → 2,4-dimethyl-pyridin-3-ol (27296-76-0)

Guidance literature:

1-benzyl-2,4-dimethyl-1,6-dihydro-2H-pyridin-3-one; With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In 1,4-dioxane; at 20 ℃; for 0.5h;

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 4h; under 760.051 Torr;

DOI:10.1021/ol8023117

Reference yield: 51.0%

3-amino-2,4-dimethylpyridine (1073-21-8) → 2,4-dimethyl-pyridin-3-ol (27296-76-0)

Guidance literature:

With sulfuric acid; sodium nitrite; a.) 0 deg C, 15 min, b.) reflux, 15 min;

DOI:10.1021/jm00098a011

upstream raw materials:

3-amino-2,4-dimethylpyridine

sulfuric acid

2,4-dimethyl-3-nitropyridine

2,4-lutidine

Downstream raw materials:

2,4-dimethyl-3-hydroxypyridine N-oxide

6-bromo-2,4-dimethyl-3-pyridinol

Refernces

• 1、 Donohoe, Timothy J.,Bower, John F.,Basutto, José A.,Fishlock, Lisa P.,Procopiou, Panayiotis A.,Callens, Cedric K.A.. "Ring-closing metathesis for the synthesis of heteroaromatics: evaluating routes to pyridines and pyridazines". scheme or table. p. 8969 - 8980. Retrieved 2009/12/26.
• 2、 -. "2-formylpyridine thiosemicarbazone compounds". . . Retrieved 2008/06/13.