4-AMINO-3,5-DIBROMOPYRIDINE

Base Information

• Chemical Name: 4-AMINO-3,5-DIBROMOPYRIDINE
• CAS No.: 84539-34-4
• Molecular Formula: C5H4Br2N2
• Molecular Weight: 251.908
• Hs Code.: 29333990
• Mol file: 84539-34-4.mol

Synonyms:Pyridine,4-amino-3,5-dibromo- (6CI);3,5-Dibromo-4-aminopyridine;3,5-Dibromo-4-pyridinamine;3,5-Dibromo-4-pyridylamine;4-Amino-3,5-dibromopyridine;

Chemical Property of 4-AMINO-3,5-DIBROMOPYRIDINE

Chemical Property:

• Vapor Pressure: 0.00179mmHg at 25°C
• Melting Point: 156-158°C
• Refractive Index: 1.672
• Boiling Point: 292.9 °C at 760 mmHg
• PKA: 4.96±0.24(Predicted)
• Flash Point: 130.9 °C
• PSA: 38.91000
• Density: 2.147 g/cm³
• LogP: 2.77000
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

4-Amino-3,5-dibromopyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,T
• Statements: 25-37/38-41
• Safety Statements: 26-45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-AMINO-3,5-DIBROMOPYRIDINE

There total 4 articles about 4-AMINO-3,5-DIBROMOPYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

4-aminopyridine (504-24-5) → 3-bromopyridin-4-amine (13534-98-0) + 4-amino-3,5-dibromopyridine (84539-34-4)

Guidance literature:

With N-Bromosuccinimide; In acetonitrile; at 20 ℃; for 48h;

DOI:10.1055/s-2001-18070

Reference yield: 55.0%

4-aminopyridine (504-24-5) → 2-bromo-4-aminopyridine (7598-35-8) + 4-amino-3,5-dibromopyridine (84539-34-4)

Guidance literature:

With N-Bromosuccinimide; In tetrachloromethane; at 20 ℃; for 48h; Darkness;

DOI:10.1007/s10593-010-0528-8

Reference yield:

isonicotinamide (1453-82-3) → 4-aminopyridine (504-24-5) + 4-amino-3,5-dibromopyridine (84539-34-4)

Guidance literature:

With potassium hydroxide; bromine; at 70 ℃;

upstream raw materials:

isonicotinamide

4-aminopyridine

bromine

Downstream raw materials:

4-[N,N-bis(2-tetrahydro-2H-pyran-2-yloxyethyl)amino]-1-(3-bromo-5-cyanopyridin-4-ylazo)-benzene

4-[N,N-bis(2-tetrahydro-2H-pyran-2-yloxyethyl)amino]-1-(3,5-dicyanopyridin-4-ylazo)benzene

4-[N,N-bis(2-tetrahydro-2H-pyran-2-yloxyethyl)amino]-1-(3-cyano-5-phenylpyridin-4-ylazo)-benzene

2-[4-N,N-bis(2-tetrahydro-2H-pyran-2-yloxyethyl)aminophenylazo-3,5-dibromopyridinium-1-yl]-1,3-dioxo-2,3-dihydro-1H-inden-2-ide

Refernces

• 1、 Canibano,Rodriguez,Santos,Sanz-Tejedor,Carreno,Gonzalez,Garcia-Ruano. "Mild regioselective halogenation of activated pyridines with N-bromosuccinimide". . p. 2175 - 2179. Retrieved 2007/10/03.