N-[[2'-(1-triphenylmethyltetrazol-5-yl)biphenyl-4-yl]methyl]valine methyl ester oxalate

Base Information

• Chemical Name: N-[[2'-(1-triphenylmethyltetrazol-5-yl)biphenyl-4-yl]methyl]valine methyl ester oxalate
• CAS No.: 1000986-63-9
• Molecular Formula: C₂H₂O₄*C₃₉H₃₇N₅O₂
• Molecular Weight: 697.791
• Mol file: 1000986-63-9.mol

Synonyms:N-[[2'-(1-triphenylmethyltetrazol-5-yl)biphenyl-4-yl]methyl]valine methyl ester oxalate

Chemical Property of N-[[2'-(1-triphenylmethyltetrazol-5-yl)biphenyl-4-yl]methyl]valine methyl ester oxalate

Chemical Property:

Purity/Quality:

HPLC≥98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[[2'-(1-triphenylmethyltetrazol-5-yl)biphenyl-4-yl]methyl]valine methyl ester oxalate

There total 3 articles about N-[[2'-(1-triphenylmethyltetrazol-5-yl)biphenyl-4-yl]methyl]valine methyl ester oxalate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

L-valine methylester hydrochloride (6306-52-1) + oxalic acid (144-62-7,97993-78-7) + N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole (124750-51-2) → N-[[2'-(1-triphenylmethyltetrazol-5-yl)biphenyl-4-yl]methyl]valine methyl ester oxalate (1000986-63-9) + C20H23N5O2 (1111177-24-2)

Guidance literature:

L-valine methylester hydrochloride; N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 25 - 50 ℃;

oxalic acid; In ethyl acetate; at 10 - 15 ℃;

DOI:10.1021/op9000912

Reference yield:

oxalic acid (144-62-7,97993-78-7) + N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole (124750-51-2) → N-[[2'-(1-triphenylmethyltetrazol-5-yl)biphenyl-4-yl]methyl]valine methyl ester oxalate (1000986-63-9)

Guidance literature:

L-valine methylester hydrochloride; N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 - 50 ℃; for 16h;

oxalic acid; In ethyl acetate; at 0 - 30 ℃; for 1h;

Reference yield:

methyl (S)-3-methyl-2-((2'-(1-triphenylmethyltetrazol-5-yl)-biphenyl-4-ylmethyl)amino)-butanoate + oxalic acid (144-62-7,97993-78-7) → N-[[2'-(1-triphenylmethyltetrazol-5-yl)biphenyl-4-yl]methyl]valine methyl ester oxalate (1000986-63-9)

Guidance literature:

In ethyl acetate; at 0 - 30 ℃; for 1h;

upstream raw materials:

oxalic acid

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole

L-valine methylester hydrochloride

Downstream raw materials:

N-[[2'-(1-triphenylmethyltetrazol-5yl)biphenyl-4-yl]methyl]-N-valeryl-L-valine methyl ester

Refernces

• 1、 Kumar N, Senthil,Reddy, Shankar B.,Sinha, Brajesh Kumar,Mukkanti, Kagga,Dandala, Ramesh. "New and improved manufacturing process for valsartan". experimental part. p. 1185 - 1189. Retrieved 2010/04/22.