2-α-chlorobenzylidenehydrazino-4-ethoxycarbonylthiazole

Base Information

• Chemical Name: 2-α-chlorobenzylidenehydrazino-4-ethoxycarbonylthiazole
• CAS No.: 136265-65-1
• Molecular Formula: C₁₃H₁₂ClN₃O₂S
• Molecular Weight: 309.776
• Mol file: 136265-65-1.mol

Synonyms:2-α-chlorobenzylidenehydrazino-4-ethoxycarbonylthiazole

Chemical Property of 2-α-chlorobenzylidenehydrazino-4-ethoxycarbonylthiazole

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 2-α-chlorobenzylidenehydrazino-4-ethoxycarbonylthiazole

There total 5 articles about 2-α-chlorobenzylidenehydrazino-4-ethoxycarbonylthiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

ethyl 2-(N'-benzoylhydrazino)thiazole-4-carboxylate (136265-64-0) → 2-α-chlorobenzylidenehydrazino-4-ethoxycarbonylthiazole (136265-65-1)

Guidance literature:

With trichlorophosphate; for 2h; Heating;

DOI:10.1007/BF01165019

Reference yield:

ethyl 2-hydrazinylthiazole-4-carboxylate (67618-34-2) → 2-α-chlorobenzylidenehydrazino-4-ethoxycarbonylthiazole (136265-65-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 64 percent / dioxane

2: 57 percent / POCl₃, POCl₅ / 2 h / Heating

With trichlorophosphate; In 1,4-dioxane;

DOI:10.1007/BF01165019

Reference yield:

benzoyl chloride (98-88-4) → 2-α-chlorobenzylidenehydrazino-4-ethoxycarbonylthiazole (136265-65-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 64 percent / dioxane

2: 57 percent / POCl₃, POCl₅ / 2 h / Heating

With trichlorophosphate; In 1,4-dioxane;

DOI:10.1007/BF01165019

upstream raw materials:

ethyl 2-(N'-benzoylhydrazino)thiazole-4-carboxylate

ethyl 2-hydrazinylthiazole-4-carboxylate

benzoyl chloride

ethyl Bromopyruvate

Downstream raw materials:

3-phenyl-5-ethoxycarbonylthiazolo<2,3-c>-1,2,4-triazole

ethyl 2-(N'-benzoylhydrazino)thiazole-4-carboxylate

Refernces

• 1、 Bredikhina, Z. A.,Buzykin, B. I.,Kitaev, Yu. P.. "SYNTHESIS AND SOME REACTIONS OF 4-CARBOXY-2-THIAZOLYLHYDRAZONES". . p. 427 - 433. Retrieved 2007/10/02.