[5'-3H]-L-DOPA

Base Information

• Chemical Name: [5'-3H]-L-DOPA
• CAS No.: 13127-57-6
• Molecular Formula: C₉H₁₁NO₄
• Molecular Weight: 199.183
• Mol file: 13127-57-6.mol

Synonyms:[5'-3H]-L-DOPA

Chemical Property of [5'-3H]-L-DOPA

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [5'-3H]-L-DOPA

There total 3 articles about [5'-3H]-L-DOPA which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

<3,5-(3)H2>-L-tyrosine (7234-03-9) → [5'-3H]-L-DOPA (13127-57-6)

Guidance literature:

With K-Pi buffer; oxygen; ascorbic acid; phenolase; at 30 ℃; for 0.5h; pH 6.0;

DOI:10.1016/0031-9422(90)85264-G

Reference yield:

L-tyrosine (60-18-4,18875-48-4,25619-78-7,30704-25-7) → [5'-3H]-L-DOPA (13127-57-6)

Guidance literature:

Multi-step reaction with 2 steps

1: THO; HCl / H₂O / 24 h / 130 °C

2: mushroom tyrosinase from Neurospora crassa (EC 1.14.18.1); phosphate buffer; ascorbic acid / H₂O / 0.33 h / 20 °C / pH 6.1

With hydrogenchloride; phosphate buffer; mushroom tyrosinase from Neurospora crassa (EC 1.14.18.1); 2,2'-thiophene-2,5-diylbis(benzoxazole); ascorbic acid; In water;

DOI:10.1002/jlcr.919

Reference yield:

L-tyrosine hydrochloride (16870-43-2,282733-43-1) → C9H10(2)HNO4 (1063716-02-8) + [5'-3H]-L-DOPA (13127-57-6)

Guidance literature:

L-tyrosine hydrochloride; With hydrogen chloride; at 130 ℃; for 24h;

With phosphate buffer; ascorbic acid; at 20 ℃; for 1h; Further stages. Title compound not separated from byproducts.;

upstream raw materials:

<3,5-(3)H2>-L-tyrosine

L-tyrosine

L-tyrosine hydrochloride

Refernces

• 1、 Kozlowska,Kanski,Kanska. "Enzymatic synthesis of tritium-labelled isotopomers of L-DOPA". . p. 235 - 240. Retrieved 2005.