Methyl 2-(piperidin-4-yl)acetate hydrochloride

Base Information

• Chemical Name: Methyl 2-(piperidin-4-yl)acetate hydrochloride
• CAS No.: 81270-37-3
• Molecular Formula: C₈H₁₅NO₂*ClH
• Molecular Weight: 193.674
• Hs Code.: 29333990
• European Community (EC) Number: 640-575-0
• DSSTox Substance ID: DTXSID90593633
• Mol file: 81270-37-3.mol

Synonyms:81270-37-3;methyl 2-(piperidin-4-yl)acetate hydrochloride;Methyl (4-Piperidyl)acetate Hydrochloride;Piperidin-4-yl-acetic acid methyl ester hydrochloride;Methyl 4-piperidineacetate hydrochloride;methyl 2-piperidin-4-ylacetate;hydrochloride;Methyl (piperidin-4-yl)acetate HCl;MFCD09261419;Methyl piperidin-4-ylacetate hydrochloride;PIPERIDIN-4-YL-ACETIC ACID METHYL ESTER HCL;4-Piperidineacetic acid, methyl ester, hydrochloride;SCHEMBL662153;(4-Piperidyl)acetic Acid Methyl Ester Hydrochloride;Methyl 4-Piperidinylacetate HCl;DTXSID90593633;ADBDFGZYGJGDNJ-UHFFFAOYSA-N;AMY25023;AKOS015845943;methyl 4-piperidylacetate hydrochloride;AB50157;CS-W001893;PS-8311;methyl-4-piperidyl-acetate-hydrochloride;AC-24845;SY014723;(4-Piperidyl)acetic acid methyl ester HCl;DB-075755;M1926;Methyl (piperidin-4-yl)acetate hydrochloride;EN300-254336;A854892;J-521711;4-PIPERIDINE ACETIC ACID METHYL ESTER HYDROCHLORIDE;Methyl (piperidin-4-yl)acetate--hydrogen chloride (1/1);Methyl 4-piperidineacetate hydrochloridePiperidin-4-yl-acetic acid methyl ester hydrochloride

Chemical Property of Methyl 2-(piperidin-4-yl)acetate hydrochloride

Chemical Property:

• Vapor Pressure: 0.0148mmHg at 25°C
• Melting Point: 155 °C
• Boiling Point: 253 °C at 760 mmHg
• Flash Point: 106.8 °C
• PSA: 38.33000
• LogP: 1.67990
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Water Solubility.: Soluble in water
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 193.0869564
• Heavy Atom Count: 12
• Complexity: 130

Purity/Quality:

98% ^*data from raw suppliers

Methyl2-(Piperidin-4-yl)acetateHydrochloride ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC(=O)CC1CCNCC1.Cl

Technology Process of Methyl 2-(piperidin-4-yl)acetate hydrochloride

There total 5 articles about Methyl 2-(piperidin-4-yl)acetate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

methyl 1-Boc-piperidin-4-ylacetate hydrochloride → methyl piperidine-4-acetate hydrochloride (81270-37-3)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 4h;

Reference yield:

1-t-Butoxycarbonyl-4-(methoxycarbonylmethyl)piperidine (175213-46-4) → methyl piperidine-4-acetate hydrochloride (81270-37-3)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 10 ℃; for 2h;

Reference yield:

methyl 4-pyridylacetate hydrochloride (70199-68-7) → methyl piperidine-4-acetate hydrochloride (81270-37-3)

Guidance literature:

With hydrogenchloride; hydrogen; platinum on activated charcoal; In methanol; diethyl ether; at 20 ℃; for 15h; under 2068.59 Torr;

upstream raw materials:

methyl 4-pyridylacetate hydrochloride

1-t-Butoxycarbonyl-4-(methoxycarbonylmethyl)piperidine

pyridin-4-yl-acetic acid ethyl ester

2-(1-(tert-butoxycarbonyl)piperidin-4-yl)acetic acid

Downstream raw materials:

C₂₆H₃₅F₂N₃O₃

benzyl 4-[4-(2-methoxy-2-oxoethyl)piperidin-1-yl]benzoate

Refernces

• 1、 -. "NOVEL ADENINE COMPOUND". Page/Page column 38-39. . Retrieved 2008/12/06.
• 2、 Deutsch, Howard M.,Dunn, Travis,Ye, Xiaocong,Schweri, Margaret M.. "Synthesis and Pharmacology of Site-Specific Cocaine Abuse Treatment Agents: The Role of the Phenyl Group in Highly Modified Methylphenidate analogs as Dopamine Uptake Inhibitors". . p. 213 - 222. Retrieved 2007/10/03.