METHYL 2-AMINO-3-MERCAPTOPROPANOATE HYDROCHLORIDE

Base Information

• Chemical Name: METHYL 2-AMINO-3-MERCAPTOPROPANOATE HYDROCHLORIDE
• CAS No.: 70361-61-4
• Molecular Formula: C₄H₁₀NO₂S*Cl
• Molecular Weight: 171.648
• Hs Code.: 29221990
• Mol file: 70361-61-4.mol

Synonyms:D-Cysteine,methyl ester, hydrochloride (9CI);(S)-Cysteine methyl ester hydrochloride;Methyl D-cysteinate hydrochloride;Methyl D-cysteinate hydrochloride (1:1);

Chemical Property of METHYL 2-AMINO-3-MERCAPTOPROPANOATE HYDROCHLORIDE

Chemical Property:

• Melting Point: 143oC
• Refractive Index: 3 ° (C=20, MeOH)
• Boiling Point: 197.2 °C at 760 mmHg
• Flash Point: 73.1 °C
• PSA: 91.12000
• LogP: 0.91880
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Water Solubility.: almost transparency

Purity/Quality:

98%,99%, ^*data from raw suppliers

D-Cysteine Methyl Ester Hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/38
• Safety Statements: 26-28-36

MSDS Files:

SDS file from LookChem

Useful:

• Uses: D-Cysteine Methyl Ester is a protected form of D-Cysteine (C995020) which is a strong inhibitor of Escherichia coli growth and also functions to provide inorganic sulfates for the sulfation of xenobiotics. D-Cysteine is a non-physiological isomer of L-Cysteine (C995000), and is not involved in protein or glutathione synthesis.

Technology Process of METHYL 2-AMINO-3-MERCAPTOPROPANOATE HYDROCHLORIDE

There total 10 articles about METHYL 2-AMINO-3-MERCAPTOPROPANOATE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methanol (67-56-1) + D-cysteine hydrochloride monohydrate (52-89-1,2564-82-1,10318-18-0,15855-92-2,32443-99-5,94706-34-0) → D-cysteine methyl ester hydrochloride (5714-80-7,18598-63-5,70361-61-4)

Guidance literature:

With hydrogenchloride; for 22h; Ambient temperature;

DOI:10.1016/S0040-4020(01)89088-8

Reference yield: 94.0%

methanol (67-56-1) + D-cysteine (921-01-7) → D-cysteine methyl ester hydrochloride (5714-80-7,18598-63-5,70361-61-4)

Guidance literature:

With acetyl chloride; at 0 ℃; for 2h; Reflux;

DOI:10.1248/cpb.c14-00578

Reference yield: 85.0%

methanol (67-56-1) + rac-cysteine (921-01-7,3374-22-9,4371-52-2,40143-64-4,40143-66-6,40143-69-9,52-90-4) → cysteine methyl ester hydrochloride (5714-80-7,18598-63-5,70361-61-4)

Guidance literature:

With chloro-trimethyl-silane; at 20 ℃; for 12h;

DOI:10.3390/molecules13051111

upstream raw materials:

methanol

rac-cysteine

D-cysteine

D-cysteine hydrochloride

Downstream raw materials:

9-methyl-5-phenyl-2,3-dihydro-thiazolo[3,2-c]quinazoline-3,10b-dicarboxylic acid 3-methyl ester

(2RS,4S)-2-Phenyl-4-thiazolidin-carbonsaeure-methylester

N-(3,5-dichlorophenyl)-2-cysteinylsuccimide methyl ester hydrochloride

(2S,5R,7R)-1-aza-7-benzyloxycarbonylamino-8-oxo-4-thiabicyclo<3.3.0>octane-2-carboxylic acid methyl ester

Refernces

• 1、 Li, Long-Bo,Dan, Wen-Jia,Tan, Fang-Fang,Cui, Li-Hui,Yuan, Zhi-Peng,Wu, Wen-Jun,Zhang, Ji-Wen. "Synthesis and antibacterial activities of Yanglingmycin analogues". . p. 33 - 37. Retrieved 2015/01/30.
• 2、 Li, Jiabo,Sha, Yaowu. "A convenient synthesis of amino acid methyl esters". . p. 1111 - 1119. Retrieved 2008/09/21.