N-cyano-N',N''-diphenylguanidine

Base Information

• Chemical Name: N-cyano-N',N''-diphenylguanidine
• CAS No.: 72751-63-4
• Molecular Formula: C₁₄H₁₂N₄
• Molecular Weight: 236.276
• Mol file: 72751-63-4.mol

Synonyms:N-cyano-N',N''-diphenylguanidine

Chemical Property of N-cyano-N',N''-diphenylguanidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-cyano-N',N''-diphenylguanidine

There total 11 articles about N-cyano-N',N''-diphenylguanidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

N,N'-diphenyl-S-methyl isothiourea (5416-30-8) + sodium cyanamide (19981-17-0,20611-81-8,123092-13-7,17292-62-5) → N-cyano-N',N''-diphenylguanidine (72751-63-4)

Guidance literature:

In isopropyl alcohol; at 80 ℃; for 0.333333h; microwave irradiation;

DOI:10.1021/ol050728q

Reference yield: 85.0%

CYANAMID (420-04-2) + 1,3-Diphenylcarbodiimide (622-16-2) → N-cyano-N',N''-diphenylguanidine (72751-63-4)

Guidance literature:

With triethylamine; In isopropyl alcohol; 1.) 25 deg C, 0.5 h, 2.) room temp., 30 min;

DOI:10.1055/s-1980-29203

Reference yield: 75.3%

aniline (62-53-3) → N-cyano-N',N''-diphenylguanidine (72751-63-4)

Guidance literature:

With sodium hydroxide; In ethanol; for 20h; Heating;

upstream raw materials:

CYANAMID

1,3-Diphenylcarbodiimide

N,N-diphenylthiourea

N-cyano-N'-phenylcarbamimidic acid phenyl ester

Refernces

• 1、 Hamilton, Sean K.,Wilkinson, Doug E.,Hamilton, Gregory S.,Wu, Yong-Qian. "Microwave-assisted synthesis of N,N′-diaryl cyanoguanidines". . p. 2429 - 2431. Retrieved 2007/10/03.
• 2、 Zupan, M.,Sket, B.,Vodopivec, J.,Zupet, P.,Molan, S.,Japelj, M.. "POLYMER SUPPORTED SYNTHESIS OF DISUBSTITUTED N-CYANOGUANIDINES". . p. 147 - 156. Retrieved 2007/10/02.