1-azido-2,4-dichlorobenzene

Base Information

• Chemical Name: 1-azido-2,4-dichlorobenzene
• CAS No.: 1965-25-9
• Molecular Formula: C₆H₃Cl₂N₃
• Molecular Weight: 188.016
• Mol file: 1965-25-9.mol

Synonyms:1-azido-2,4-dichlorobenzene

Chemical Property of 1-azido-2,4-dichlorobenzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-azido-2,4-dichlorobenzene

There total 11 articles about 1-azido-2,4-dichlorobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2,4-Dichloroaniline (554-00-7,51908-09-9) → 1-azido-2,4-dichlorobenzene (1965-25-9)

Guidance literature:

With tert.-butylnitrite; trimethylsilylazide; In acetonitrile; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.1055/s-0034-1379887

Reference yield: 54.0%

2,4-dichloro-1-iodo-benzene (29898-32-6) → 1-azido-2,4-dichlorobenzene (1965-25-9)

Guidance literature:

With copper(l) iodide; sodium azide; trans-N,N'-dimethylcyclohexane-1,2-diamine; sodium L-ascorbate; In water; dimethyl sulfoxide; at 100 ℃; for 2h;

DOI:10.1016/j.bmcl.2008.11.110

Reference yield:

5-Chloro-2-azidoaniline (75458-14-9) → 1-azido-2,4-dichlorobenzene (1965-25-9)

Guidance literature:

With hydrogenchloride; water; sodium nitrite; Yield given. Multistep reaction;

DOI:10.1021/jo01314a002

upstream raw materials:

2,4-Dichloroaniline

5-Chloro-2-azidoaniline

5-chloro-2-nitroaniline

4-Chloro-2-phthalimidoaniline

Downstream raw materials:

HS₅₇-6

HS₅₇-2

ethyl 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-1H-1,2,3-triazole-4-carboxylate

HS₅₇-9

Refernces

• 1、 Aisa, Haji Akber,Cao, Jianguo,Guo, Hongmei,Huang, Guozheng,Jin, Xin,Wang, Qi,Zhao, Qingjie. "Synthesis of new derivatives of alepterolic acid via click chemistry". . p. 917 - 925. Retrieved 2021/11/16.
• 2、 Ahmad, Abrar,Alam, Mohammad Mahboob,Alfaifi, Sulaiman Y. M.,Alghamdi, Abdullah A. A.,Ali, Nada M.,Almalki, Abdulraheem S. A.,Alsharif, Meshari A.,Elhenawy, Ahmed A.,Malebari, Azizah M.,Nazreen, Syed. "Synthesis and biological evaluation of 1,2,3-triazole tethered thymol-1,3,4-oxadiazole derivatives as anticancer and antimicrobial agents". . . Retrieved 2021/10/05.