2-Bromomethyl-4-fluorophenylboronic acid pinacol ester

Base Information

• Chemical Name: 2-Bromomethyl-4-fluorophenylboronic acid pinacol ester
• CAS No.: 850567-57-6
• Molecular Formula: C13H17BBrFO2
• Molecular Weight: 314.99
• Hs Code.: 2934999090
• Mol file: 850567-57-6.mol

Synonyms:2-(Bromomethyl)-4-fluorobenzeneboronic acid, pinacol ester 95%;

Chemical Property of 2-Bromomethyl-4-fluorophenylboronic acid pinacol ester

Chemical Property:

• Vapor Pressure: 7.81E-05mmHg at 25°C
• Melting Point: 47-48℃
• Refractive Index: 1.513
• Boiling Point: 352.4 °C at 760 mmHg
• Flash Point: 166.9 °C
• PSA: 18.46000
• Density: 1.31 g/cm³
• LogP: 3.01980
• Storage Temp.: Keep Cold

Purity/Quality:

98%min ^*data from raw suppliers

2-Bromomethyl-4-fluorophenylboronicacid,pinacolester ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Bromomethyl-4-fluorophenylboronic acid pinacol ester

There total 1 articles about 2-Bromomethyl-4-fluorophenylboronic acid pinacol ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(4-fluoro-2-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (815631-56-2) → 2-(bromomethyl)-4-fluorophenylboronic acid pinacol ester (850567-57-6)

Guidance literature:

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In tetrachloromethane; at 76 ℃; for 16h; Inert atmosphere;

DOI:10.1002/chem.201901145

Reference yield: 37.0%

2-(bromomethyl)-4-fluorophenylboronic acid pinacol ester (850567-57-6) + 9-[N-[3-(methacrylamido)propylamino]methyl]-10-[N-[2-(tert-butoxycarbonyl)ethylamino]methyl]-anthracene (1030832-19-9) → 9-[N-[6-(4,4,5,5,-tetramethyl-1,3,2-dioxaborolano)-3-fluorobenzyl]-N-[3-(methacrylamido)propylamino]methyl]-10-[N-[6-(4,4,5,5,-tetramethyl-1,3,2-dioxaborolano)-3-fluorobenzyl]-N-[2-(tert-butoxycarbonyl)ethylamino]methyl]anthracene (1030832-53-1)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 80 ℃; for 18h;

Reference yield: 12.0%

2-(bromomethyl)-4-fluorophenylboronic acid pinacol ester (850567-57-6) → tavaborole (174671-46-6) + 3-(bromomethyl)-5-fluorobenzene-1,2-diol (1447933-60-9) + 5-fluoro-2-hydroxy-benzyl alcohol (2357-33-7)

Guidance literature:

With dihydrogen peroxide; In dimethyl sulfoxide; at 20 ℃; for 336h;

DOI:10.1002/chem.201300539

upstream raw materials:

2-(4-fluoro-2-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Downstream raw materials:

9-[N-[6-(4,4,5,5,-tetramethyl-1,3,2-dioxaborolano)-3-fluorobenzyl]-N-[3-(methacrylamido)propylamino]methyl]-10-[N-[6-(4,4,5,5,-tetramethyl-1,3,2-dioxaborolano)-3-fluorobenzyl]-N-[2-(tert-butoxycarbonyl)ethylamino]methyl]anthracene

trimethyl-[2-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-5-fluorobenzyl]-quaternaryammonium bromide

C₁₀H₁₆BFNO₂⁽¹⁺⁾*Br^(1-)

pinacolboronic acid

Refernces