2-Cyano-5-bromomethylpyridine

Base Information

• Chemical Name: 2-Cyano-5-bromomethylpyridine
• CAS No.: 308846-06-2
• Molecular Formula: C7H5BrN2
• Molecular Weight: 197.034
• Hs Code.: 2933399090
• Mol file: 308846-06-2.mol

Synonyms:5-(Bromomethyl)-2-pyridinecarbonitrile;5-(Bromomethyl)pyridin-2-carbonitrile;5-Bromomethyl-2-cyanopyridine;

Chemical Property of 2-Cyano-5-bromomethylpyridine

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.592
• Boiling Point: 329.5 ºC at 760 mmHg
• PKA: -1.23±0.10(Predicted)
• Flash Point: 153.1 ºC
• PSA: 36.68000
• Density: 1.607 g/cm³
• LogP: 1.84818
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

5-(Bromomethyl)pyridine-2-carbonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Cyano-5-bromomethylpyridine

There total 5 articles about 2-Cyano-5-bromomethylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

5-methylpicolinonitrile (1620-77-5) + N-Bromosuccinimide (128-08-5) → 5-(bromomethyl)pyridine-2-carbonitrile (308846-06-2)

Guidance literature:

With 2,2'-azobis(isobutyronitrile); In acetonitrile; for 12h; Reflux;

DOI:10.3390/ph15020245

Reference yield: 53.0%

5-methylpicolinonitrile (1620-77-5) → 5-(bromomethyl)pyridine-2-carbonitrile (308846-06-2)

Guidance literature:

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In chloroform; at 60 ℃; for 6h;

Reference yield: 51.0%

5-methylpicolinonitrile (1620-77-5) + dibenzoyl peroxide (94-36-0) → 5-(bromomethyl)pyridine-2-carbonitrile (308846-06-2)

Guidance literature:

With N-Bromosuccinimide; In tetrachloromethane;

upstream raw materials:

5-methylpicolinonitrile

2-Bromo-5-methylpyridine

dibenzoyl peroxide

N-Bromosuccinimide

Downstream raw materials:

5-(aminomethyl)pyridine-2-carboximidamide

C₂₅H₂₄FN₃O

N-((6-cyanopyridin-3-yl)methyl)-4-fluoro-N-(pentan-3-yl)benzenesulfonamide

N-((6-cyanopyridin-3-yl)methyl)-4-chloro-N-(pentan-3-yl)benzenesulfonamide

Refernces

• 1、 -. "ANALOGUES OF PENTAMIDINE AND USES THEREFOR". Paragraph 0248. . Retrieved 2020/07/14.
• 2、 Huang, Qi,Zard, Samir Z.. "Modular Route to Azaindanes". supporting information. p. 3895 - 3898. Retrieved 2017/07/26.