Pygenic acid A

Base Information

• Chemical Name: Pygenic acid A
• CAS No.: 52213-27-1
• Molecular Formula: C₃₀H₄₈O₄
• Molecular Weight: 472.709
• Mol file: 52213-27-1.mol

Synonyms:2a,3a-Dihydroxyurs-12-en-28-oic acid; 3-Epicorosolic acid;3-epi-Corosolic acid; Pygenic acid A

Chemical Property of Pygenic acid A

Chemical Property:

• PSA: 77.76000
• LogP: 6.06030

Purity/Quality:

99% ^*data from raw suppliers

3-Epicorosolicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Pygenic acid A

There total 14 articles about Pygenic acid A which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

benzyl-2α,3β-dihydroxyurs-12-en-28-oic acid (869788-73-8) → corosolic acid (4547-24-4,52213-27-1,72881-13-1,87205-98-9,114580-53-9)

Guidance literature:

With hydrogen; palladium on activated charcoal; In tetrahydrofuran; at 20 ℃;

DOI:10.1016/j.bmcl.2005.08.026

Reference yield: 85.0%

2α-hydroxy-3-oxourosolic acid (132473-94-0) → 2α-hydroxy-ursolic acid (4547-24-4,52213-27-1,72881-13-1,87205-98-9,114580-53-9)

Guidance literature:

With sodium tetrahydroborate; In ethanol; at 0 ℃;

Reference yield:

(2α,3β)-2,3-bis(acetyloxy)-urs-12-en-28-oic acid (57498-76-7) → corosolic acid (4547-24-4,52213-27-1,72881-13-1,87205-98-9,114580-53-9)

Guidance literature:

With methanol; potassium hydroxide; at 20 ℃; for 2h;

upstream raw materials:

methyl corosolate

2α,3α-diacetoxyurs-12-en-28-oic acid

methyl 2α,3β-diacetoxyurs-12-en-28-oate

benzyl-2α,3β-dihydroxyurs-12-en-28-oic acid

Downstream raw materials:

benzyl-2α,3β-dihydroxyurs-12-en-28-oic acid

3β-acetoxy-2α-hydroxyurs-12-en-28-oic acid

2α,3α-diacetoxyurs-12-en-28-oic acid

2α,3β,28-trihydroxyurs-12-ene

Refernces

• 1、 Fu, Shaobin,Meng, Qingfeng,Long, Shu-An,Zhang, Yun,Sun, Di-An,Wei, Gang. "Biocatalytic Synthesis of the Anti-diabetes Agent-corosolic Acid by Whole Cells of Microorganisms". . p. 871 - 874. Retrieved 2015/10/29.
• 2、 -. "Process for preparing high purity corosolic acid and high purity ursolic acid". Page/Page column 5-6. . Retrieved 2008/12/04.