(2S)-2-Methylpiperazine dihydrochloride

Base Information

• Chemical Name: (2S)-2-Methylpiperazine dihydrochloride
• CAS No.: 475640-80-3
• Molecular Formula: C5H12N2^.2(HCl)
• Molecular Weight: 173.08
• Mol file: 475640-80-3.mol

Synonyms:Piperazine,2-methyl-, monohydrochloride, (2S)- (9CI);

Chemical Property of (2S)-2-Methylpiperazine dihydrochloride

Chemical Property:

• PSA: 24.06000
• LogP: 1.82930

Purity/Quality:

98%Min ^*data from raw suppliers

(2S)-2-METHYLPIPERAZINE DIHYDROCHLORIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2S)-2-Methylpiperazine dihydrochloride

There total 6 articles about (2S)-2-Methylpiperazine dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

propylene glycol (57-55-6,63625-56-9) + ethylenediamine (107-15-3,85404-18-8) → (+/-)-2-methylpiperazine bis(hydrochloride) (13264-88-5,66918-24-9,75336-85-5,75336-89-9,93334-99-7,475640-80-3)

Guidance literature:

With bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; sodium hydrogencarbonate; In water; at 140 ℃; for 17h; Inert atmosphere; Heating;

DOI:10.1002/ejoc.201201099

Reference yield: 69.0%

ethylene glycol (107-21-1) + 1,2-diaminopropan (78-90-0,10424-38-1) → (+/-)-2-methylpiperazine bis(hydrochloride) (13264-88-5,66918-24-9,75336-85-5,75336-89-9,93334-99-7,475640-80-3)

Guidance literature:

With bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; sodium hydrogencarbonate; In toluene; at 140 ℃; for 17h; Inert atmosphere; Heating;

DOI:10.1002/ejoc.201201099

Reference yield: 19.0%

(S)-3-methyl-2,5-piperazinedione (4526-77-6) → (S)-(-)-2-methylpiperazine dihydrochloride (13264-88-5,66918-24-9,75336-85-5,75336-89-9,93334-99-7,475640-80-3)

Guidance literature:

With hydrogenchloride; sodium bis(2-methoxyethoxy)aluminium dihydride; In benzene; for 48h; Heating;

upstream raw materials:

ethylene glycol

1,2-diaminopropan

propylene glycol

ethylenediamine

Refernces

• 1、 Lorentz-Petersen, Linda L. R.,Nordstrom, Lars Ulrik,Madsen, Robert. "Iridium-catalyzed condensation of amines and vicinal diols to substituted piperazines". . p. 6752 - 6759. Retrieved 2013/01/15.